H-MeArg-(Tos)-D-Leu-NHEt

Base Information

• Chemical Name: H-MeArg-(Tos)-D-Leu-NHEt
• CAS No.: 103638-92-2
• Molecular Formula: C₂₂H₃₈N₆O₄S
• Molecular Weight: 482.648
• Mol file: 103638-92-2.mol

Synonyms:H-MeArg-(Tos)-D-Leu-NHEt

Chemical Property of H-MeArg-(Tos)-D-Leu-NHEt

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of H-MeArg-(Tos)-D-Leu-NHEt

There total 2 articles about H-MeArg-(Tos)-D-Leu-NHEt which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

Z-MeArg(Tos)-D-Leu-NHEt (103613-69-0) → H-MeArg-(Tos)-D-Leu-NHEt (103638-92-2)

Guidance literature:

With hydrogen; palladium on activated charcoal; under 760 Torr;

DOI:10.1021/jm00163a034

Reference yield:

Z-MeArg(Tos)-OH (62937-37-5) → H-MeArg-(Tos)-D-Leu-NHEt (103638-92-2)

Guidance literature:

Multi-step reaction with 2 steps

1: 1.) ethyl chloroformate, N-methylmorpholine, 2.) triethylamine / 1.) THF, -20 deg C, 5 min, 2.) 0 deg C, 2 h

2: H₂ / Pd/C (10percent) / 760 Torr

With 4-methyl-morpholine; hydrogen; chloroformic acid ethyl ester; triethylamine; palladium on activated charcoal;

DOI:10.1021/jm00163a034

Reference yield: 59.0%

Boc-Arg(Tos)-OH (13836-37-8) + H-MeArg-(Tos)-D-Leu-NHEt (103638-92-2) → Boc-Arg(Tos)-MeArg(Tos)-D-Leu-NHEt (103613-72-5)

Guidance literature:

With benzotriazol-1-ol; dicyclohexyl-carbodiimide; In N,N-dimethyl-formamide; 1.) 4 deg C, overnight, 2.) RT, 30 h;

DOI:10.1021/jm00163a034

upstream raw materials:

Z-MeArg(Tos)-D-Leu-NHEt

Z-MeArg(Tos)-OH

Downstream raw materials:

Boc-Arg(Tos)-MeArg(Tos)-D-Leu-NHEt

TFA*H-Arg(Tos)-MeArg(Tos)-D-Leu-NHEt