5-(5-bromo-3-chlorothiophen-2-yl)-3-(2,6-difluorophenyl)-1-methyl-1H-[1,2,4]triazole

Base Information

Chemical Name:5-(5-bromo-3-chlorothiophen-2-yl)-3-(2,6-difluorophenyl)-1-methyl-1H-[1,2,4]triazole
CAS No.:503309-07-7
Molecular Formula:C₁₃H₇BrClF₂N₃S
Molecular Weight:390.638
Hs Code.:

Synonyms:5-(5-bromo-3-chlorothiophen-2-yl)-3-(2,6-difluorophenyl)-1-methyl-1H-[1,2,4]triazole

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Chemical Property of 5-(5-bromo-3-chlorothiophen-2-yl)-3-(2,6-difluorophenyl)-1-methyl-1H-[1,2,4]triazole

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Technology Process of 5-(5-bromo-3-chlorothiophen-2-yl)-3-(2,6-difluorophenyl)-1-methyl-1H-[1,2,4]triazole

There total 1 articles about 5-(5-bromo-3-chlorothiophen-2-yl)-3-(2,6-difluorophenyl)-1-methyl-1H-[1,2,4]triazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 51.0%

: 214407-80-4
C₁₃H₈ClF₂N₃S

: 503309-07-7
5-(5-bromo-3-chlorothiophen-2-yl)-3-(2,6-difluorophenyl)-1-methyl-1H-[1,2,4]triazole

Guidance literature:: With bromine; sodium acetate; acetic acid; at 75 ℃; for 37h;
DOI:10.1021/jf071498s

Reference yield: 69.0%

: 503309-07-7
5-(5-bromo-3-chlorothiophen-2-yl)-3-(2,6-difluorophenyl)-1-methyl-1H-[1,2,4]triazole

: 5720-05-8
4-methylphenylboronic acid

: 503308-07-4
5-(3-chloro-5-p-tolylthiophen-2-yl)-3-(2,6-difluorophenyl)-1-methyl-1H-[1,2,4]triazole

Guidance literature:: With sodium carbonate; tris-(o-tolyl)phosphine; bis-triphenylphosphine-palladium(II) chloride; In water; acetonitrile; for 20h; Heating;
DOI:10.1021/jf071498s

Reference yield: 65.0%

: 503309-07-7
5-(5-bromo-3-chlorothiophen-2-yl)-3-(2,6-difluorophenyl)-1-methyl-1H-[1,2,4]triazole

: 139301-27-2
4-trifluoromethoxyphenylboronic acid

: 503308-06-3
5-[3-chloro-5-(4-trifluoromethoxyphenyl)thiophen-2-yl]-3-(2,6-difluorophenyl)-1-methyl-1H-[1,2,4]triazole

Guidance literature:: With sodium carbonate; tris-(o-tolyl)phosphine; bis-triphenylphosphine-palladium(II) chloride; In water; acetonitrile; for 20h; Heating;
DOI:10.1021/jf071498s