(2R,5S,8S)-1-aza-8-benzyloxycarbonylamino-9-oxo-4-thiabicyclo[3.4.0]nonane-2-carboxylic acid methyl ester

Base Information

Chemical Name:(2R,5S,8S)-1-aza-8-benzyloxycarbonylamino-9-oxo-4-thiabicyclo[3.4.0]nonane-2-carboxylic acid methyl ester
CAS No.:131990-88-0
Molecular Formula:C₁₇H₂₀N₂O₅S
Molecular Weight:364.422
Hs Code.:

Synonyms:(2R,5S,8S)-1-aza-8-benzyloxycarbonylamino-9-oxo-4-thiabicyclo[3.4.0]nonane-2-carboxylic acid methyl ester

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Chemical Property of (2R,5S,8S)-1-aza-8-benzyloxycarbonylamino-9-oxo-4-thiabicyclo[3.4.0]nonane-2-carboxylic acid methyl ester

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Technology Process of (2R,5S,8S)-1-aza-8-benzyloxycarbonylamino-9-oxo-4-thiabicyclo[3.4.0]nonane-2-carboxylic acid methyl ester

There total 5 articles about (2R,5S,8S)-1-aza-8-benzyloxycarbonylamino-9-oxo-4-thiabicyclo[3.4.0]nonane-2-carboxylic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 66.0%

: 131990-87-9
N-(hydroxymethyl)-Cbz-L-BTD-OMe

: 131990-88-0
(2R,5S,8S)-1-aza-8-benzyloxycarbonylamino-9-oxo-4-thiabicyclo[3.4.0]nonane-2-carboxylic acid methyl ester

Guidance literature:: With sodium carbonate; In methanol; for 4h; Ambient temperature;
DOI:10.1021/ja00102a008

Reference yield: 32.0%

: 89969-26-6
(S)-3-(3-benzyloxycarbonyl-5-oxo-1,3-oxazolidin-4-yl)propionaldehyde

: 18598-63-5
L-cysteine methyl ester hydrochloride

: 131990-88-0
(2R,5S,8S)-1-aza-8-benzyloxycarbonylamino-9-oxo-4-thiabicyclo[3.4.0]nonane-2-carboxylic acid methyl ester

Guidance literature:: (S)-3-(3-benzyloxycarbonyl-5-oxo-1,3-oxazolidin-4-yl)propionaldehyde; L-cysteine methyl ester hydrochloride; With pyridine; at 20 - 50 ℃; for 87h; Inert atmosphere;

With potassium carbonate; In methanol; for 4h;

In methanol;
DOI:10.1021/jm901013a

Reference yield:

: 89969-26-6
(S)-3-(3-benzyloxycarbonyl-5-oxo-1,3-oxazolidin-4-yl)propionaldehyde

: 131990-88-0
(2R,5S,8S)-1-aza-8-benzyloxycarbonylamino-9-oxo-4-thiabicyclo[3.4.0]nonane-2-carboxylic acid methyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 71 percent / pyridine / 120 h / Ambient temperature

2: 66 percent / Na₂CO₃ / methanol / 4 h / Ambient temperature

With pyridine; sodium carbonate; In methanol;
DOI:10.1021/ja00102a008