2-(4-bromo-phenylsulfanyl)-N-[3-(4,5-dihydro-oxazol-2-yl)-1-phenethyl-1H-pyrazol-4-yl]-acetamide

Base Information

Chemical Name:2-(4-bromo-phenylsulfanyl)-N-[3-(4,5-dihydro-oxazol-2-yl)-1-phenethyl-1H-pyrazol-4-yl]-acetamide
CAS No.:1021497-98-2
Molecular Formula:C₂₂H₂₁BrN₄O₂S
Molecular Weight:485.404
Hs Code.:

Synonyms:2-(4-bromo-phenylsulfanyl)-N-[3-(4,5-dihydro-oxazol-2-yl)-1-phenethyl-1H-pyrazol-4-yl]-acetamide

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Chemical Property of 2-(4-bromo-phenylsulfanyl)-N-[3-(4,5-dihydro-oxazol-2-yl)-1-phenethyl-1H-pyrazol-4-yl]-acetamide

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Technology Process of 2-(4-bromo-phenylsulfanyl)-N-[3-(4,5-dihydro-oxazol-2-yl)-1-phenethyl-1H-pyrazol-4-yl]-acetamide

There total 6 articles about 2-(4-bromo-phenylsulfanyl)-N-[3-(4,5-dihydro-oxazol-2-yl)-1-phenethyl-1H-pyrazol-4-yl]-acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 1021498-24-7
4-[2-(4-bromo-phenylsulfanyl)-acetylamino]-1-phenethyl-1H-pyrazole-3-carboxylic acid (2-chloro-ethyl)-amide

: 1021497-98-2
2-(4-bromo-phenylsulfanyl)-N-[3-(4,5-dihydro-oxazol-2-yl)-1-phenethyl-1H-pyrazol-4-yl]-acetamide

Guidance literature:: With 1,8-diazabicyclo[5.4.0]undec-7-ene; In tetrahydrofuran; Reflux; Inert atmosphere;

Reference yield:

: 1021498-05-4
methyl 4-nitro-1-(2-phenylethyl)-1H-pyrazole-3-carboxylate

: 1021497-98-2
2-(4-bromo-phenylsulfanyl)-N-[3-(4,5-dihydro-oxazol-2-yl)-1-phenethyl-1H-pyrazol-4-yl]-acetamide

Guidance literature:: Multi-step reaction with 6 steps

1.1: hydrogen / palladium 10% on activated carbon / methanol / 0.5 h / 30402 Torr

2.1: triethylamine / tetrahydrofuran / 24 h

3.1: triethylamine / tetrahydrofuran / 1 h

4.1: sodium hydroxide; water / methanol / 1 h

5.1: dmap; 2,2'-dipyridyl carbonate / tetrahydrofuran / 0.5 h

5.2: 1 h

6.1: 1,8-diazabicyclo[5.4.0]undec-7-ene / tetrahydrofuran / 3 h / Heating / reflux

With dmap; sodium hydroxide; 2,2'-dipyridyl carbonate; water; hydrogen; 1,8-diazabicyclo[5.4.0]undec-7-ene; triethylamine; palladium 10% on activated carbon; In tetrahydrofuran; methanol;

Reference yield:

: 103-63-9
1-phenyl-2-bromoethane

: 1021497-98-2
2-(4-bromo-phenylsulfanyl)-N-[3-(4,5-dihydro-oxazol-2-yl)-1-phenethyl-1H-pyrazol-4-yl]-acetamide

Guidance literature:: Multi-step reaction with 7 steps

1.1: caesium carbonate / N,N-dimethyl-formamide / 24 h

2.1: hydrogen / palladium 10% on activated carbon / methanol / 0.5 h / 30402 Torr

3.1: triethylamine / tetrahydrofuran / 24 h

4.1: triethylamine / tetrahydrofuran / 1 h

5.1: sodium hydroxide; water / methanol / 1 h

6.1: dmap; 2,2'-dipyridyl carbonate / tetrahydrofuran / 0.5 h

6.2: 1 h

7.1: 1,8-diazabicyclo[5.4.0]undec-7-ene / tetrahydrofuran / 3 h / Heating / reflux

With dmap; sodium hydroxide; 2,2'-dipyridyl carbonate; water; hydrogen; caesium carbonate; 1,8-diazabicyclo[5.4.0]undec-7-ene; triethylamine; palladium 10% on activated carbon; In tetrahydrofuran; methanol; N,N-dimethyl-formamide;