tert-butyl (3R)-3-[4-amino-3-[4-(2,5-difluorophenoxy)phenyl]-1H-pyrazolo[3,4-d]pyrimidin-1-yl]piperidine-1-carboxylate

Base Information

Chemical Name:tert-butyl (3R)-3-[4-amino-3-[4-(2,5-difluorophenoxy)phenyl]-1H-pyrazolo[3,4-d]pyrimidin-1-yl]piperidine-1-carboxylate
CAS No.:1414356-71-0
Molecular Formula:C₂₇H₂₈F₂N₆O₃
Molecular Weight:522.555
Hs Code.:

Synonyms:tert-butyl (3R)-3-[4-amino-3-[4-(2,5-difluorophenoxy)phenyl]-1H-pyrazolo[3,4-d]pyrimidin-1-yl]piperidine-1-carboxylate

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Chemical Property of tert-butyl (3R)-3-[4-amino-3-[4-(2,5-difluorophenoxy)phenyl]-1H-pyrazolo[3,4-d]pyrimidin-1-yl]piperidine-1-carboxylate

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Technology Process of tert-butyl (3R)-3-[4-amino-3-[4-(2,5-difluorophenoxy)phenyl]-1H-pyrazolo[3,4-d]pyrimidin-1-yl]piperidine-1-carboxylate

There total 11 articles about tert-butyl (3R)-3-[4-amino-3-[4-(2,5-difluorophenoxy)phenyl]-1H-pyrazolo[3,4-d]pyrimidin-1-yl]piperidine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

: 1276110-38-3
(R)-3-(4-amino-3-iodo-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidine-1-carboxylic acid tert-butyl ester

: 1414356-70-9
2-[4-(2,5-difluorophenoxy)phenyl]-4,4,5,5-tetramethyl-1,3,2-dioxaborolane

: 1414356-71-0
tert-butyl (3R)-3-[4-amino-3-[4-(2,5-difluorophenoxy)phenyl]-1H-pyrazolo[3,4-d]pyrimidin-1-yl]piperidine-1-carboxylate

Guidance literature:: With sodium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,4-dioxane; water; at 90 ℃; for 12h;

Reference yield:

: 2713-31-7
2,5-difluorophenol

: 1414356-71-0
tert-butyl (3R)-3-[4-amino-3-[4-(2,5-difluorophenoxy)phenyl]-1H-pyrazolo[3,4-d]pyrimidin-1-yl]piperidine-1-carboxylate

Guidance literature:: Multi-step reaction with 5 steps

1.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 2.33 h / 0 - 25 °C / Inert atmosphere

1.2: 12 h / 100 °C

2.1: hydrazine hydrate / methanol / 12 h / 25 °C / Inert atmosphere

3.1: hydrogenchloride; sodium nitrite / water / 0.58 h / 0 °C

3.2: 12 h / 25 °C

4.1: potassium acetate / palladium diacetate / N,N-dimethyl-formamide / 12 h / 85 °C / Inert atmosphere

5.1: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane; water / 12 h / 90 °C

With hydrogenchloride; potassium acetate; sodium hydride; sodium carbonate; hydrazine hydrate; sodium nitrite; tetrakis(triphenylphosphine) palladium⁽⁰⁾; palladium diacetate; In 1,4-dioxane; methanol; water; N,N-dimethyl-formamide; mineral oil;

Reference yield:

: 350-46-9,178603-76-4
4-Fluoronitrobenzene

: 1414356-71-0
tert-butyl (3R)-3-[4-amino-3-[4-(2,5-difluorophenoxy)phenyl]-1H-pyrazolo[3,4-d]pyrimidin-1-yl]piperidine-1-carboxylate

Guidance literature:: Multi-step reaction with 5 steps

1.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 2.33 h / 0 - 25 °C / Inert atmosphere

1.2: 12 h / 100 °C

2.1: hydrazine hydrate / methanol / 12 h / 25 °C / Inert atmosphere

3.1: hydrogenchloride; sodium nitrite / water / 0.58 h / 0 °C

3.2: 12 h / 25 °C

4.1: potassium acetate / palladium diacetate / N,N-dimethyl-formamide / 12 h / 85 °C / Inert atmosphere

5.1: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane; water / 12 h / 90 °C

With hydrogenchloride; potassium acetate; sodium hydride; sodium carbonate; hydrazine hydrate; sodium nitrite; tetrakis(triphenylphosphine) palladium⁽⁰⁾; palladium diacetate; In 1,4-dioxane; methanol; water; N,N-dimethyl-formamide; mineral oil;