6-Vinyl-benzo[1,3]dioxole-5-carboxylic acid benzyl-((E)-4-oxo-but-2-enyl)-amide

Base Information

Chemical Name:6-Vinyl-benzo[1,3]dioxole-5-carboxylic acid benzyl-((E)-4-oxo-but-2-enyl)-amide
CAS No.:79809-10-2
Molecular Formula:C₂₁H₁₉NO₄
Molecular Weight:349.386
Hs Code.:

Synonyms:6-Vinyl-benzo[1,3]dioxole-5-carboxylic acid benzyl-((E)-4-oxo-but-2-enyl)-amide

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Chemical Property of 6-Vinyl-benzo[1,3]dioxole-5-carboxylic acid benzyl-((E)-4-oxo-but-2-enyl)-amide

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Technology Process of 6-Vinyl-benzo[1,3]dioxole-5-carboxylic acid benzyl-((E)-4-oxo-but-2-enyl)-amide

There total 5 articles about 6-Vinyl-benzo[1,3]dioxole-5-carboxylic acid benzyl-((E)-4-oxo-but-2-enyl)-amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 72473-19-9
6-vinylbenzo[1,3]dioxole-5-carboxylic acid

: 79809-10-2
6-Vinyl-benzo[1,3]dioxole-5-carboxylic acid benzyl-((E)-4-oxo-but-2-enyl)-amide

Guidance literature:: Multi-step reaction with 3 steps

1: triethylamine, methanesulfonylchloride / CH₂Cl₂

2: NaH / dimethylformamide / 18 h / 23 °C

3: 1.) PPTS, MeOH, reflux 2.) Corey-Suggs oxidation

With sodium hydride; methanesulfonyl chloride; triethylamine; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/S0040-4039(01)92951-X

Reference yield:

: 15930-53-7
6-bromo-3,4-methylenedioxybenzaldehyde

: 79809-10-2
6-Vinyl-benzo[1,3]dioxole-5-carboxylic acid benzyl-((E)-4-oxo-but-2-enyl)-amide

Guidance literature:: Multi-step reaction with 5 steps

1: tetrahydrofuran / 0 °C / Wittig methenylation

2: 1.) n-BuLi in ether at -65 deg C 2.) gaseous CO₂ at -40 deg C

3: triethylamine, methanesulfonylchloride / CH₂Cl₂

4: NaH / dimethylformamide / 18 h / 23 °C

5: 1.) PPTS, MeOH, reflux 2.) Corey-Suggs oxidation

With sodium hydride; methanesulfonyl chloride; triethylamine; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/S0040-4039(01)92951-X

Reference yield:

: 79809-07-7
6-Vinyl-benzo[1,3]dioxole-5-carboxylic acid benzylamide

: 79809-10-2
6-Vinyl-benzo[1,3]dioxole-5-carboxylic acid benzyl-((E)-4-oxo-but-2-enyl)-amide

Guidance literature:: Multi-step reaction with 2 steps

1: NaH / dimethylformamide / 18 h / 23 °C

2: 1.) PPTS, MeOH, reflux 2.) Corey-Suggs oxidation

With sodium hydride; In N,N-dimethyl-formamide;
DOI:10.1016/S0040-4039(01)92951-X