tert-butyl {[4-(4-methylphenyl)-2-(2-methylpropyl)-6-(5-oxo-4,5-dihydro-1,2,4-oxadiazol-3-yl)quinolin-3-yl]methyl}carbamate

Base Information

Chemical Name:tert-butyl {[4-(4-methylphenyl)-2-(2-methylpropyl)-6-(5-oxo-4,5-dihydro-1,2,4-oxadiazol-3-yl)quinolin-3-yl]methyl}carbamate
CAS No.:660451-57-0
Molecular Formula:C₂₈H₃₂N₄O₄
Molecular Weight:488.586
Hs Code.:

Synonyms:tert-butyl {[4-(4-methylphenyl)-2-(2-methylpropyl)-6-(5-oxo-4,5-dihydro-1,2,4-oxadiazol-3-yl)quinolin-3-yl]methyl}carbamate

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Chemical Property of tert-butyl {[4-(4-methylphenyl)-2-(2-methylpropyl)-6-(5-oxo-4,5-dihydro-1,2,4-oxadiazol-3-yl)quinolin-3-yl]methyl}carbamate

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Technology Process of tert-butyl {[4-(4-methylphenyl)-2-(2-methylpropyl)-6-(5-oxo-4,5-dihydro-1,2,4-oxadiazol-3-yl)quinolin-3-yl]methyl}carbamate

There total 16 articles about tert-butyl {[4-(4-methylphenyl)-2-(2-methylpropyl)-6-(5-oxo-4,5-dihydro-1,2,4-oxadiazol-3-yl)quinolin-3-yl]methyl}carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 1330530-00-1,662145-02-0
tert-butyl [6-[(Z)-amino(hydroxyimino)methyl]-2-isobutyl-4-(4-methylphenyl)quinolin-3-yl]methylcarbamate

: 530-62-1
1,1'-carbonyldiimidazole

: 660451-57-0
tert-butyl {[4-(4-methylphenyl)-2-(2-methylpropyl)-6-(5-oxo-4,5-dihydro-1,2,4-oxadiazol-3-yl)quinolin-3-yl]methyl}carbamate

Guidance literature:: In tetrahydrofuran; ethyl acetate; for 3h; Heating / reflux;

Reference yield: 90.0%

: 1330530-00-1,662145-02-0
tert-butyl {[6-(hydroxycarbamimidoyl)-4-(4-methylphenyl)-2-(2-methylpropyl)quinolin-3-yl]methyl}carbamate

: 530-62-1
1,1'-carbonyldiimidazole

: 660451-57-0
tert-butyl {[4-(4-methylphenyl)-2-(2-methylpropyl)-6-(5-oxo-4,5-dihydro-1,2,4-oxadiazol-3-yl)quinolin-3-yl]methyl}carbamate

Guidance literature:: In tetrahydrofuran; ethyl acetate; for 3h; Reflux;
DOI:10.1016/j.bmc.2011.06.032

Reference yield:

: C₂₁H₂₄N₂O

: 660451-57-0
tert-butyl {[4-(4-methylphenyl)-2-(2-methylpropyl)-6-(5-oxo-4,5-dihydro-1,2,4-oxadiazol-3-yl)quinolin-3-yl]methyl}carbamate

Guidance literature:: Multi-step reaction with 5 steps

1: tetrahydrofuran / 96 h / 20 °C

2: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.5 h / 0 °C

3: tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1-methyl-pyrrolidin-2-one / 2 h / 80 °C / Inert atmosphere

4: hydroxylamine hydrochloride; potassium tert-butylate / ethanol / 6 h / 70 °C

5: tetrahydrofuran; ethyl acetate / 3 h / Reflux

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; hydroxylamine hydrochloride; potassium tert-butylate; sodium hydride; In tetrahydrofuran; 1-methyl-pyrrolidin-2-one; ethanol; ethyl acetate; N,N-dimethyl-formamide; mineral oil;
DOI:10.1016/j.bmc.2011.06.032