methyl 3-(N-methyl-N-tosylamino)-2,2-dimethyl-3-(p-methoxyphenyl)propionate

Base Information

• Chemical Name: methyl 3-(N-methyl-N-tosylamino)-2,2-dimethyl-3-(p-methoxyphenyl)propionate
• CAS No.: 1445315-84-3
• Molecular Formula: C₂₁H₂₇NO₅S
• Molecular Weight: 405.515
• Mol file: 1445315-84-3.mol

Synonyms:methyl 3-(N-methyl-N-tosylamino)-2,2-dimethyl-3-(p-methoxyphenyl)propionate

Chemical Property of methyl 3-(N-methyl-N-tosylamino)-2,2-dimethyl-3-(p-methoxyphenyl)propionate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of methyl 3-(N-methyl-N-tosylamino)-2,2-dimethyl-3-(p-methoxyphenyl)propionate

There total 2 articles about methyl 3-(N-methyl-N-tosylamino)-2,2-dimethyl-3-(p-methoxyphenyl)propionate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 53.0%

1-methoxy-2-methyl-1-trimethylsiloxy-1-propene (31469-15-5) + N-methyl-N-tosyl-p-methoxybenzamide (1445317-61-2) → methyl 3-(N-methyl-N-tosylamino)-2,2-dimethyl-3-(p-methoxyphenyl)propionate (1445315-84-3)

Guidance literature:

With indium (III) iodide; phenylsilane; In dichloromethane; at 20 ℃; for 12h;

DOI:10.1021/ol4015317

Reference yield:

4-methoxybenzoic acid (100-09-4) + N-methyl-p-toluenesulfonylamide (640-61-9) → methyl 3-(N-methyl-N-tosylamino)-2,2-dimethyl-3-(p-methoxyphenyl)propionate (1445315-84-3)

Guidance literature:

Multi-step reaction with 2 steps

1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; dmap / dichloromethane / 0 - 20 °C

2: indium (III) iodide; phenylsilane / dichloromethane / 12 h / 20 °C

With dmap; indium (III) iodide; phenylsilane; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In dichloromethane;

DOI:10.1021/ol4015317

upstream raw materials:

4-methoxybenzoic acid

N-methyl-p-toluenesulfonylamide

1-methoxy-2-methyl-1-trimethylsiloxy-1-propene

N-methyl-N-tosyl-p-methoxybenzamide