(S)-2-ethyl-5-isobutyl-7-methyl-3-(5-(2-(1-trityl-1H-tetrazol-5-yl)phenyl)-2,3-dihydro-1H-inden-1-yl)-3H-imidazo[4,5-b]pyridine

Base Information

• Chemical Name: (S)-2-ethyl-5-isobutyl-7-methyl-3-(5-(2-(1-trityl-1H-tetrazol-5-yl)phenyl)-2,3-dihydro-1H-inden-1-yl)-3H-imidazo[4,5-b]pyridine
• CAS No.: 1310693-03-8
• Molecular Formula: C₄₈H₄₅N₇
• Molecular Weight: 719.932
• Mol file: 1310693-03-8.mol

Synonyms:(S)-2-ethyl-5-isobutyl-7-methyl-3-(5-(2-(1-trityl-1H-tetrazol-5-yl)phenyl)-2,3-dihydro-1H-inden-1-yl)-3H-imidazo[4,5-b]pyridine

Chemical Property of (S)-2-ethyl-5-isobutyl-7-methyl-3-(5-(2-(1-trityl-1H-tetrazol-5-yl)phenyl)-2,3-dihydro-1H-inden-1-yl)-3H-imidazo[4,5-b]pyridine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (S)-2-ethyl-5-isobutyl-7-methyl-3-(5-(2-(1-trityl-1H-tetrazol-5-yl)phenyl)-2,3-dihydro-1H-inden-1-yl)-3H-imidazo[4,5-b]pyridine

There total 4 articles about (S)-2-ethyl-5-isobutyl-7-methyl-3-(5-(2-(1-trityl-1H-tetrazol-5-yl)phenyl)-2,3-dihydro-1H-inden-1-yl)-3H-imidazo[4,5-b]pyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

(S)-3-(5-bromo-2,3-dihydro-1H-inden-1-yl)-2-ethyl-5-isobutyl-7-methyl-3H-imidazo[4,5-b]pyridine (1310692-89-7) + 2-(N-triphenylmethyl-tetrazol-5-yl)-phenylboronic acid (144873-97-2) → (S)-2-ethyl-5-isobutyl-7-methyl-3-(5-(2-(1-trityl-1H-tetrazol-5-yl)phenyl)-2,3-dihydro-1H-inden-1-yl)-3H-imidazo[4,5-b]pyridine (1310693-03-8)

Guidance literature:

With palladium diacetate; potassium carbonate; triphenylphosphine; In 1,2-dimethoxyethane; water; at 80 ℃; for 18h; Inert atmosphere;

DOI:10.1021/jm200409s

Reference yield:

(R)-5-(2-(1-trityl-1H-tetrazol-5-yl)phenyl)-2,3-dihydro-1H-inden-1-ol (1038919-82-2) + 2-ethyl-5-isobutyl-7-methyl-3H-imidazo[4,5-b]pyridine (1260880-00-9) + 2-ethyl-7-isobutyl-5-methyl-3H-imidazo[4,5-b]pyridine (1310692-77-3) → (S)-2-ethyl-7-isobutyl-5-methyl-3-(5-(2-(1-trityl-1H-tetrazol-5-yl)phenyl)-2,3-dihydro-1H-inden-1-yl)-3H-imidazo[4,5-b]pyridine (1310693-05-0) + (S)-2-ethyl-5-isobutyl-7-methyl-3-(5-(2-(1-trityl-1H-tetrazol-5-yl)phenyl)-2,3-dihydro-1H-inden-1-yl)-3H-imidazo[4,5-b]pyridine (1310693-03-8)

Guidance literature:

With triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; at 0 - 25 ℃; Inert atmosphere;

DOI:10.1021/jm200409s

Reference yield:

2-ethyl-5-isobutyl-7-methyl-3H-imidazo[4,5-b]pyridine (1260880-00-9) → (S)-2-ethyl-5-isobutyl-7-methyl-3-(5-(2-(1-trityl-1H-tetrazol-5-yl)phenyl)-2,3-dihydro-1H-inden-1-yl)-3H-imidazo[4,5-b]pyridine (1310693-03-8)

Guidance literature:

Multi-step reaction with 2 steps

1: triphenylphosphine; diethylazodicarboxylate / tetrahydrofuran / 25 °C / Inert atmosphere; Cooling

2: palladium diacetate; potassium carbonate; triphenylphosphine / 1,2-dimethoxyethane; water / 18 h / 80 °C / Inert atmosphere

With palladium diacetate; potassium carbonate; triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; 1,2-dimethoxyethane; water; 1: Mitsunobu reaction / 2: Suzuki coupling;

DOI:10.1021/jm200409s

upstream raw materials:

2-ethyl-5-isobutyl-7-methyl-3H-imidazo[4,5-b]pyridine

(R)-5-(2-(1-trityl-1H-tetrazol-5-yl)phenyl)-2,3-dihydro-1H-inden-1-ol

2-ethyl-7-isobutyl-5-methyl-3H-imidazo[4,5-b]pyridine

(S)-3-(5-bromo-2,3-dihydro-1H-inden-1-yl)-2-ethyl-5-isobutyl-7-methyl-3H-imidazo[4,5-b]pyridine

Downstream raw materials:

(S)-3-(5-(2-(1H-tetrazol-5-yl)phenyl)-2,3-dihydro-1H-inden-1-yl)-2-ethyl-5-isobutyl-7-methyl-3H-imidazo[4,5-b]pyridine