(E)-2-[(2-ethoxycarbonyl)ethenyl]-4-(phenylthio)-N-toluenesulfonyl-1,2,3,6-tetrahydropyridine

Base Information

Chemical Name:(E)-2-[(2-ethoxycarbonyl)ethenyl]-4-(phenylthio)-N-toluenesulfonyl-1,2,3,6-tetrahydropyridine
CAS No.:1315323-37-5
Molecular Formula:C₂₃H₂₅NO₄S₂
Molecular Weight:443.588
Hs Code.:

Synonyms:(E)-2-[(2-ethoxycarbonyl)ethenyl]-4-(phenylthio)-N-toluenesulfonyl-1,2,3,6-tetrahydropyridine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (E)-2-[(2-ethoxycarbonyl)ethenyl]-4-(phenylthio)-N-toluenesulfonyl-1,2,3,6-tetrahydropyridine

Chemical Property:

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Technology Process of (E)-2-[(2-ethoxycarbonyl)ethenyl]-4-(phenylthio)-N-toluenesulfonyl-1,2,3,6-tetrahydropyridine

There total 5 articles about (E)-2-[(2-ethoxycarbonyl)ethenyl]-4-(phenylthio)-N-toluenesulfonyl-1,2,3,6-tetrahydropyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₁₉H₁₉NO₃S₂

: 1099-45-2
ethyl (triphenylphosphoranylidene)acetate

: 1315323-37-5
(E)-2-[(2-ethoxycarbonyl)ethenyl]-4-(phenylthio)-N-toluenesulfonyl-1,2,3,6-tetrahydropyridine

Guidance literature:: In dichloromethane; at 20 ℃; for 12h;
DOI:10.1016/j.tet.2011.05.086

Reference yield:

: 4083-64-1
Tosyl isocyanate

: 1315323-37-5
(E)-2-[(2-ethoxycarbonyl)ethenyl]-4-(phenylthio)-N-toluenesulfonyl-1,2,3,6-tetrahydropyridine

Guidance literature:: Multi-step reaction with 5 steps

1.1: toluene / 36 h / Reflux

2.1: toluene / 20 h / Reflux

3.1: lithium aluminium tetrahydride / tetrahydrofuran / 2 h

4.1: oxalyl dichloride; dimethyl sulfoxide / dichloromethane / 0.5 h

4.2: 0.33 h

5.1: dichloromethane / 12 h / 20 °C

With lithium aluminium tetrahydride; oxalyl dichloride; dimethyl sulfoxide; In tetrahydrofuran; dichloromethane; toluene; 2.1: Diels-Alder reaction / 4.1: Swern oxidation / 4.2: Swern oxidation;
DOI:10.1016/j.tet.2011.05.086

Reference yield:

: 1315323-35-3
ethyl 4-(phenylthio)-N-toluenesulfonyl-1,2,3,6-tetrahydro-2-pyridinecarboxylate

: 1315323-37-5
(E)-2-[(2-ethoxycarbonyl)ethenyl]-4-(phenylthio)-N-toluenesulfonyl-1,2,3,6-tetrahydropyridine

Guidance literature:: Multi-step reaction with 3 steps

1.1: lithium aluminium tetrahydride / tetrahydrofuran / 2 h

2.1: oxalyl dichloride; dimethyl sulfoxide / dichloromethane / 0.5 h

2.2: 0.33 h

3.1: dichloromethane / 12 h / 20 °C

With lithium aluminium tetrahydride; oxalyl dichloride; dimethyl sulfoxide; In tetrahydrofuran; dichloromethane; 2.1: Swern oxidation / 2.2: Swern oxidation;
DOI:10.1016/j.tet.2011.05.086