(13aS)-8-hydroxy-7,9-dioxo-N-(2,4,6-trifluorobenzyl)-2,3,4,5,7,9,13,13a-octahydro-2,5-methanopyrido[1',2':4,5]pyrazmo[2,1-b][1,3]oxazepine-10-carboxamide

Base Information

Chemical Name:(13aS)-8-hydroxy-7,9-dioxo-N-(2,4,6-trifluorobenzyl)-2,3,4,5,7,9,13,13a-octahydro-2,5-methanopyrido[1',2':4,5]pyrazmo[2,1-b][1,3]oxazepine-10-carboxamide
CAS No.:1616340-12-5
Molecular Formula:C₂₁H₁₈F₃N₃O₅
Molecular Weight:449.386
Hs Code.:

Synonyms:(13aS)-8-hydroxy-7,9-dioxo-N-(2,4,6-trifluorobenzyl)-2,3,4,5,7,9,13,13a-octahydro-2,5-methanopyrido[1',2':4,5]pyrazmo[2,1-b][1,3]oxazepine-10-carboxamide

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Chemical Property of (13aS)-8-hydroxy-7,9-dioxo-N-(2,4,6-trifluorobenzyl)-2,3,4,5,7,9,13,13a-octahydro-2,5-methanopyrido[1',2':4,5]pyrazmo[2,1-b][1,3]oxazepine-10-carboxamide

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Technology Process of (13aS)-8-hydroxy-7,9-dioxo-N-(2,4,6-trifluorobenzyl)-2,3,4,5,7,9,13,13a-octahydro-2,5-methanopyrido[1',2':4,5]pyrazmo[2,1-b][1,3]oxazepine-10-carboxamide

There total 4 articles about (13aS)-8-hydroxy-7,9-dioxo-N-(2,4,6-trifluorobenzyl)-2,3,4,5,7,9,13,13a-octahydro-2,5-methanopyrido[1',2':4,5]pyrazmo[2,1-b][1,3]oxazepine-10-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1616340-97-6
C₂₂H₂₀F₃N₃O₅

: 1616340-12-5
(13aS)-8-hydroxy-7,9-dioxo-N-(2,4,6-trifluorobenzyl)-2,3,4,5,7,9,13,13a-octahydro-2,5-methanopyrido[1',2':4,5]pyrazmo[2,1-b][1,3]oxazepine-10-carboxamide

Guidance literature:: With magnesium bromide; In acetonitrile; at 50 ℃; for 1h;

Reference yield:

: 1616340-75-0
1-(2,2-dihydroxyethyl)-5-methoxy-6-(methoxycarbonyl)-4-oxo-1,4-dihydropyridine-3-carboxylic acid

: 1616340-12-5
(13aS)-8-hydroxy-7,9-dioxo-N-(2,4,6-trifluorobenzyl)-2,3,4,5,7,9,13,13a-octahydro-2,5-methanopyrido[1',2':4,5]pyrazmo[2,1-b][1,3]oxazepine-10-carboxamide

Guidance literature:: Multi-step reaction with 3 steps

1: potassium carbonate / acetonitrile / 16 h / 20 - 85 °C

2: N-ethyl-N,N-diisopropylamine; HATU / acetonitrile / 2 h / 20 °C

3: magnesium bromide / acetonitrile / 1 h / 50 °C

With potassium carbonate; N-ethyl-N,N-diisopropylamine; HATU; magnesium bromide; In acetonitrile;

Reference yield:

: 1335210-23-5
1-[2,2-bis(methyloxy)ethyl]-5-(methyloxy)-6-[(methyloxy)carbonyl]-4-oxo-1,4-dihydro-3-pyridinecarboxylic acid

: 1616340-12-5
(13aS)-8-hydroxy-7,9-dioxo-N-(2,4,6-trifluorobenzyl)-2,3,4,5,7,9,13,13a-octahydro-2,5-methanopyrido[1',2':4,5]pyrazmo[2,1-b][1,3]oxazepine-10-carboxamide

Guidance literature:: Multi-step reaction with 4 steps

1: methanesulfonic acid; acetic acid / acetonitrile / 81 h / -10 - 75 °C

2: potassium carbonate / acetonitrile / 16 h / 20 - 85 °C

3: N-ethyl-N,N-diisopropylamine; HATU / acetonitrile / 2 h / 20 °C

4: magnesium bromide / acetonitrile / 1 h / 50 °C

With methanesulfonic acid; potassium carbonate; acetic acid; N-ethyl-N,N-diisopropylamine; HATU; magnesium bromide; In acetonitrile;