(R)-2-[2-(3-{(R)-2-[2-(3-Amino-prop-1-ynyl)-phenylamino]-propionylamino}-prop-1-ynyl)-phenylamino]-4-methyl-pentanoic acid

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Chemical Name:(R)-2-[2-(3-{(R)-2-[2-(3-Amino-prop-1-ynyl)-phenylamino]-propionylamino}-prop-1-ynyl)-phenylamino]-4-methyl-pentanoic acid
CAS No.:744185-23-7
Molecular Formula:C₂₇H₃₂N₄O₃
Molecular Weight:460.576
Hs Code.:

Synonyms:(R)-2-[2-(3-{(R)-2-[2-(3-Amino-prop-1-ynyl)-phenylamino]-propionylamino}-prop-1-ynyl)-phenylamino]-4-methyl-pentanoic acid

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Chemical Property of (R)-2-[2-(3-{(R)-2-[2-(3-Amino-prop-1-ynyl)-phenylamino]-propionylamino}-prop-1-ynyl)-phenylamino]-4-methyl-pentanoic acid

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Technology Process of (R)-2-[2-(3-{(R)-2-[2-(3-Amino-prop-1-ynyl)-phenylamino]-propionylamino}-prop-1-ynyl)-phenylamino]-4-methyl-pentanoic acid

There total 11 articles about (R)-2-[2-(3-{(R)-2-[2-(3-Amino-prop-1-ynyl)-phenylamino]-propionylamino}-prop-1-ynyl)-phenylamino]-4-methyl-pentanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

: 227288-28-0
(R)-2-[2-(3-{(R)-2-[2-(3-tert-Butoxycarbonylamino-prop-1-ynyl)-phenylamino]-propionylamino}-prop-1-ynyl)-phenylamino]-4-methyl-pentanoic acid

: 744185-23-7
(R)-2-[2-(3-{(R)-2-[2-(3-Amino-prop-1-ynyl)-phenylamino]-propionylamino}-prop-1-ynyl)-phenylamino]-4-methyl-pentanoic acid

Guidance literature:: With hydrogenchloride; In ethyl acetate; at -20 ℃; for 0.333333h;
DOI:10.1016/S0040-4039(99)00534-1

Reference yield:

: 227288-15-5
tert-butyl [3-(2-aminophenyl)prop-2-yn-1-yl]carbamate

: 744185-23-7
(R)-2-[2-(3-{(R)-2-[2-(3-Amino-prop-1-ynyl)-phenylamino]-propionylamino}-prop-1-ynyl)-phenylamino]-4-methyl-pentanoic acid

Guidance literature:: Multi-step reaction with 5 steps

1: 82 percent / 2,6-lutidine / 1,2-dichloro-ethane / 18 h / 60 °C

2: 95 percent / HCl / ethyl acetate / 0.33 h / -20 °C

3: 48 percent / EDCl, DIPEA, HOBt / dimethylformamide / 3 h / 0 °C

4: 93 percent / LiOH / methanol / 24 h / Ambient temperature

5: 99 percent / HCl / ethyl acetate / 0.33 h / -20 °C

With 2,6-dimethylpyridine; hydrogenchloride; lithium hydroxide; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In methanol; ethyl acetate; 1,2-dichloro-ethane; N,N-dimethyl-formamide;
DOI:10.1016/S0040-4039(99)00534-1

Reference yield:

: 13748-90-8,498-36-2
(S)-2-hydroxyl-3,3-dimethylbutyric acid

: 744185-23-7
(R)-2-[2-(3-{(R)-2-[2-(3-Amino-prop-1-ynyl)-phenylamino]-propionylamino}-prop-1-ynyl)-phenylamino]-4-methyl-pentanoic acid

Guidance literature:: Multi-step reaction with 7 steps

1: 84 percent / SOCl₂ / 2 h / Heating

2: 91 percent / 2,6-lutidine / CH₂Cl₂ / -78 °C

3: 82 percent / 2,6-lutidine / 1,2-dichloro-ethane / 18 h / 60 °C

4: 95 percent / HCl / ethyl acetate / 0.33 h / -20 °C

5: 48 percent / EDCl, DIPEA, HOBt / dimethylformamide / 3 h / 0 °C

6: 93 percent / LiOH / methanol / 24 h / Ambient temperature

7: 99 percent / HCl / ethyl acetate / 0.33 h / -20 °C

With 2,6-dimethylpyridine; hydrogenchloride; lithium hydroxide; thionyl chloride; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In methanol; dichloromethane; ethyl acetate; 1,2-dichloro-ethane; N,N-dimethyl-formamide;
DOI:10.1016/S0040-4039(99)00534-1