N-[4-(6-hydroxy-3-oxo-3H-xanthen-9-yl)-3-methylbenzoyl]-β-alanyl-N-(3-{(3β)-cholest-5-en-3-yl[(2-nitrophenyl)sulfonyl]amino}propyl)-β-alaninamide

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Chemical Name:N-[4-(6-hydroxy-3-oxo-3H-xanthen-9-yl)-3-methylbenzoyl]-β-alanyl-N-(3-{(3β)-cholest-5-en-3-yl[(2-nitrophenyl)sulfonyl]amino}propyl)-β-alaninamide
CAS No.:879288-22-9
Molecular Formula:C₆₃H₇₉N₅O₁₀S
Molecular Weight:1098.41
Hs Code.:

Synonyms:N-[4-(6-hydroxy-3-oxo-3H-xanthen-9-yl)-3-methylbenzoyl]-β-alanyl-N-(3-{(3β)-cholest-5-en-3-yl[(2-nitrophenyl)sulfonyl]amino}propyl)-β-alaninamide

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Chemical Property of N-[4-(6-hydroxy-3-oxo-3H-xanthen-9-yl)-3-methylbenzoyl]-β-alanyl-N-(3-{(3β)-cholest-5-en-3-yl[(2-nitrophenyl)sulfonyl]amino}propyl)-β-alaninamide

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Technology Process of N-[4-(6-hydroxy-3-oxo-3H-xanthen-9-yl)-3-methylbenzoyl]-β-alanyl-N-(3-{(3β)-cholest-5-en-3-yl[(2-nitrophenyl)sulfonyl]amino}propyl)-β-alaninamide

There total 6 articles about N-[4-(6-hydroxy-3-oxo-3H-xanthen-9-yl)-3-methylbenzoyl]-β-alanyl-N-(3-{(3β)-cholest-5-en-3-yl[(2-nitrophenyl)sulfonyl]amino}propyl)-β-alaninamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 876752-79-3
Tokyo Green succinimidyl ester

: 879288-20-7
3-amino-N-(2-{3-[[17-(1,5-dimethyl-hexyl)-10,13-dimethyl-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-3-yl]-(2-nitro-benzenesulfonyl)-amino]-propylcarbamoyl}-ethyl)-propionamide

: 879288-22-9
N-[4-(6-hydroxy-3-oxo-3H-xanthen-9-yl)-3-methylbenzoyl]-β-alanyl-N-(3-{(3β)-cholest-5-en-3-yl[(2-nitrophenyl)sulfonyl]amino}propyl)-β-alaninamide

Guidance literature:: With potassium carbonate; In dimethyl sulfoxide; at 22 ℃; for 24h;
DOI:10.1021/ol052655g

Reference yield:

: 879288-19-4
4-(6-hydroxy-3-oxo-3H-xanthen-9-yl)-3-methylbenzoic acid methyl ester

: 879288-22-9
N-[4-(6-hydroxy-3-oxo-3H-xanthen-9-yl)-3-methylbenzoyl]-β-alanyl-N-(3-{(3β)-cholest-5-en-3-yl[(2-nitrophenyl)sulfonyl]amino}propyl)-β-alaninamide

Guidance literature:: Multi-step reaction with 3 steps

1: 99 percent / LiOH / methanol; H₂O / 1 h

2: DCC; N-hydroxysuccinimide / tetrahydrofuran / 2 h / 22 °C

3: 19.1 mg / K₂CO₃ / dimethylsulfoxide / 24 h / 22 °C

With lithium hydroxide; 1-hydroxy-pyrrolidine-2,5-dione; potassium carbonate; dicyclohexyl-carbodiimide; In tetrahydrofuran; methanol; water; dimethyl sulfoxide;
DOI:10.1021/ol052655g

Reference yield:

: 876752-68-0
4-(6-hydroxy-3-oxo-3H-xanthen-9-yl)-3-methylbenzoic acid

: 879288-22-9
N-[4-(6-hydroxy-3-oxo-3H-xanthen-9-yl)-3-methylbenzoyl]-β-alanyl-N-(3-{(3β)-cholest-5-en-3-yl[(2-nitrophenyl)sulfonyl]amino}propyl)-β-alaninamide

Guidance literature:: Multi-step reaction with 2 steps

1: DCC; N-hydroxysuccinimide / tetrahydrofuran / 2 h / 22 °C

2: 19.1 mg / K₂CO₃ / dimethylsulfoxide / 24 h / 22 °C

With 1-hydroxy-pyrrolidine-2,5-dione; potassium carbonate; dicyclohexyl-carbodiimide; In tetrahydrofuran; dimethyl sulfoxide;
DOI:10.1021/ol052655g