(3S,5S,6S)-3-[(1S,5R)-5-(tert-butyldiphenylsilyloxy)-1-(methoxymethoxy)hexyl]-5,6-bis-(4-methoxyphenyl)-[1,4]-dioxan-2-one

Base Information

Chemical Name:(3S,5S,6S)-3-[(1S,5R)-5-(tert-butyldiphenylsilyloxy)-1-(methoxymethoxy)hexyl]-5,6-bis-(4-methoxyphenyl)-[1,4]-dioxan-2-one
CAS No.:918328-68-4
Molecular Formula:C₄₂H₅₂O₈Si
Molecular Weight:712.956
Hs Code.:

Synonyms:(3S,5S,6S)-3-[(1S,5R)-5-(tert-butyldiphenylsilyloxy)-1-(methoxymethoxy)hexyl]-5,6-bis-(4-methoxyphenyl)-[1,4]-dioxan-2-one

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Chemical Property of (3S,5S,6S)-3-[(1S,5R)-5-(tert-butyldiphenylsilyloxy)-1-(methoxymethoxy)hexyl]-5,6-bis-(4-methoxyphenyl)-[1,4]-dioxan-2-one

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Technology Process of (3S,5S,6S)-3-[(1S,5R)-5-(tert-butyldiphenylsilyloxy)-1-(methoxymethoxy)hexyl]-5,6-bis-(4-methoxyphenyl)-[1,4]-dioxan-2-one

There total 11 articles about (3S,5S,6S)-3-[(1S,5R)-5-(tert-butyldiphenylsilyloxy)-1-(methoxymethoxy)hexyl]-5,6-bis-(4-methoxyphenyl)-[1,4]-dioxan-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 4705-34-4,15638-14-9,34480-01-8,112246-67-0,2510-75-0
1,2-bis(4-methoxyphenyl)ethene

: 918328-68-4
(3S,5S,6S)-3-[(1S,5R)-5-(tert-butyldiphenylsilyloxy)-1-(methoxymethoxy)hexyl]-5,6-bis-(4-methoxyphenyl)-[1,4]-dioxan-2-one

Guidance literature:: Multi-step reaction with 3 steps

1.1: 84 percent / K₃Fe(CN)6; potassium carbonate; methanesulfonamide / (DHQ)2PHAL; K₂OsO₂(OH)4 / H₂O; 2-methyl-propan-2-ol / 30 h / 20 °C

2.1: dibutyltin oxide / benzene / 24 h / Heating

2.2: 55 percent / tetra n-butylammonium iodide / benzene / 48 h / Heating

3.1: dicyclohexylboron triflate; triethylamine / CH₂Cl₂; hexane / 3 h / -78 °C

3.2: CH₂Cl₂; hexane / 15 h / -78 °C

3.3: N,N-diisopropylamine; tetra n-butylammonium iodide / CH₂Cl₂ / 336 h / 20 °C

With methanesulfonamide; di(n-butyl)tin oxide; potassium carbonate; triethylamine; potassium hexacyanoferrate(III); dicyclohexyl(((trifluoromethyl)sulfonyl)oxy)borane; Hydroquinone 1,4-phthalazinediyl diether; potassium dioxotetrahydroxoosmate(VI); In hexane; dichloromethane; water; tert-butyl alcohol; benzene; 3.2: aldol reaction;
DOI:10.1021/ol062479r

Reference yield:

: 1145-93-3
diethyl 4-methoxybenzylphosphonate

: 918328-68-4
(3S,5S,6S)-3-[(1S,5R)-5-(tert-butyldiphenylsilyloxy)-1-(methoxymethoxy)hexyl]-5,6-bis-(4-methoxyphenyl)-[1,4]-dioxan-2-one

Guidance literature:: Multi-step reaction with 4 steps

1.1: potassium carbonate / dimethylformamide / 0.33 h / cooling

1.2: 85 percent / dimethylformamide / 1 h / 20 °C

2.1: 84 percent / K₃Fe(CN)6; potassium carbonate; methanesulfonamide / (DHQ)2PHAL; K₂OsO₂(OH)4 / H₂O; 2-methyl-propan-2-ol / 30 h / 20 °C

3.1: dibutyltin oxide / benzene / 24 h / Heating

3.2: 55 percent / tetra n-butylammonium iodide / benzene / 48 h / Heating

4.1: dicyclohexylboron triflate; triethylamine / CH₂Cl₂; hexane / 3 h / -78 °C

4.2: CH₂Cl₂; hexane / 15 h / -78 °C

4.3: N,N-diisopropylamine; tetra n-butylammonium iodide / CH₂Cl₂ / 336 h / 20 °C

With methanesulfonamide; di(n-butyl)tin oxide; potassium carbonate; triethylamine; potassium hexacyanoferrate(III); dicyclohexyl(((trifluoromethyl)sulfonyl)oxy)borane; Hydroquinone 1,4-phthalazinediyl diether; potassium dioxotetrahydroxoosmate(VI); In hexane; dichloromethane; water; N,N-dimethyl-formamide; tert-butyl alcohol; benzene; 1.2: Horner-Wadsworth-Emmons olefination / 4.2: aldol reaction;
DOI:10.1021/ol062479r

Reference yield:

: 2746-25-0
p-Methoxybenzyl bromide

: 918328-68-4
(3S,5S,6S)-3-[(1S,5R)-5-(tert-butyldiphenylsilyloxy)-1-(methoxymethoxy)hexyl]-5,6-bis-(4-methoxyphenyl)-[1,4]-dioxan-2-one

Guidance literature:: Multi-step reaction with 5 steps

1.1: 95 percent / 5 h / Heating

2.1: potassium carbonate / dimethylformamide / 0.33 h / cooling

2.2: 85 percent / dimethylformamide / 1 h / 20 °C

3.1: 84 percent / K₃Fe(CN)6; potassium carbonate; methanesulfonamide / (DHQ)2PHAL; K₂OsO₂(OH)4 / H₂O; 2-methyl-propan-2-ol / 30 h / 20 °C

4.1: dibutyltin oxide / benzene / 24 h / Heating

4.2: 55 percent / tetra n-butylammonium iodide / benzene / 48 h / Heating

5.1: dicyclohexylboron triflate; triethylamine / CH₂Cl₂; hexane / 3 h / -78 °C

5.2: CH₂Cl₂; hexane / 15 h / -78 °C

5.3: N,N-diisopropylamine; tetra n-butylammonium iodide / CH₂Cl₂ / 336 h / 20 °C

With methanesulfonamide; di(n-butyl)tin oxide; potassium carbonate; triethylamine; potassium hexacyanoferrate(III); dicyclohexyl(((trifluoromethyl)sulfonyl)oxy)borane; Hydroquinone 1,4-phthalazinediyl diether; potassium dioxotetrahydroxoosmate(VI); In hexane; dichloromethane; water; N,N-dimethyl-formamide; tert-butyl alcohol; benzene; 2.2: Horner-Wadsworth-Emmons olefination / 5.2: aldol reaction;
DOI:10.1021/ol062479r