C₃₂H₄₅N₄O₁₂PSSi

Base Information

Chemical Name:C₃₂H₄₅N₄O₁₂PSSi
CAS No.:1397776-01-0
Molecular Formula:C₃₂H₄₅N₄O₁₂PSSi
Molecular Weight:768.854
Hs Code.:

C<sub>32</sub>H<sub>45</sub>N<sub>4</sub>O<sub>12</sub>PSSi

Synonyms:C₃₂H₄₅N₄O₁₂PSSi

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Chemical Property of C₃₂H₄₅N₄O₁₂PSSi

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Technology Process of C₃₂H₄₅N₄O₁₂PSSi

There total 5 articles about C₃₂H₄₅N₄O₁₂PSSi which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 53.0%

: 1397775-99-3
C₂₂H₃₂N₂O₅SSi

: 98796-51-1
5'-O-(4,4'-dimethoxytrityl)-2'-deoxythymidine-3'-O-[O-(2-cyanoethyl)-N,N'-diisopropylphosphoramidite]

: 1397776-01-0
C₃₂H₄₅N₄O₁₂PSSi

Guidance literature:: C₂₂H₃₂N₂O₅SSi; 5'-O-(4,4'-dimethoxytrityl)-2'-deoxythymidine-3'-O-[O-(2-cyanoethyl)-N,N'-diisopropylphosphoramidite]; With 4,5-dicyano-1H-imidazole; In acetonitrile; for 0.5h; Inert atmosphere;

With pyridine; iodine; In water; acetonitrile; Further stages; Inert atmosphere;
DOI:10.1002/anie.201209454

Reference yield:

: 40733-26-4
3',5'-O-di(tert-butyldimethylsilyl)thymidine

: 1397776-01-0
C₃₂H₄₅N₄O₁₂PSSi

Guidance literature:: Multi-step reaction with 4 steps

1.1: N-Bromosuccinimide; dibenzoyl peroxide / tetrachloromethane / Inert atmosphere; Reflux

2.1: triethylamine / N,N-dimethyl-formamide / 24 h / 70 °C / Inert atmosphere

3.1: water; trifluoroacetic acid / dichloromethane / 4 h / 0 °C / Inert atmosphere

4.1: 4,5-dicyano-1H-imidazole / acetonitrile / 0.5 h / Inert atmosphere

4.2: Inert atmosphere

With N-Bromosuccinimide; 4,5-dicyano-1H-imidazole; water; triethylamine; trifluoroacetic acid; dibenzoyl peroxide; In tetrachloromethane; dichloromethane; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1002/anie.201209454

Reference yield:

: 50-89-5,28854-96-8,3545-96-8,50-88-4
thymidine

: 1397776-01-0
C₃₂H₄₅N₄O₁₂PSSi

Guidance literature:: Multi-step reaction with 5 steps

1.1: 1H-imidazole / N,N-dimethyl-formamide / Inert atmosphere

2.1: N-Bromosuccinimide; dibenzoyl peroxide / tetrachloromethane / Inert atmosphere; Reflux

3.1: triethylamine / N,N-dimethyl-formamide / 24 h / 70 °C / Inert atmosphere

4.1: water; trifluoroacetic acid / dichloromethane / 4 h / 0 °C / Inert atmosphere

5.1: 4,5-dicyano-1H-imidazole / acetonitrile / 0.5 h / Inert atmosphere

5.2: Inert atmosphere

With 1H-imidazole; N-Bromosuccinimide; 4,5-dicyano-1H-imidazole; water; triethylamine; trifluoroacetic acid; dibenzoyl peroxide; In tetrachloromethane; dichloromethane; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1002/anie.201209454