2-benzyl-2,4-diphenylbut-3-ynal

Base Information

• Chemical Name: 2-benzyl-2,4-diphenylbut-3-ynal
• CAS No.: 1448349-80-1
• Molecular Formula: C₂₃H₁₈O
• Molecular Weight: 310.395

Synonyms:2-benzyl-2,4-diphenylbut-3-ynal

Chemical Property of 2-benzyl-2,4-diphenylbut-3-ynal

Chemical Property:

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Technology Process of 2-benzyl-2,4-diphenylbut-3-ynal

There total 4 articles about 2-benzyl-2,4-diphenylbut-3-ynal which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 62.0%

N-allyl-N-(3-hydroxy-1,3,5-triphenylpent-4-yn-2-yl)-4-methylbenzenesulfonamide → 1-allyl-2-benzyl-3,5-diphenyl-1H-pyrrole (1448349-79-8) + 2-benzyl-2,4-diphenylbut-3-ynal (1448349-80-1)

Guidance literature:

With 1,3‐bis[2,6‐bis(propan‐2‐yl)phenyl]‐2‐[(phenylformonitrile)aurio]‐2,3‐dihydro‐1H‐imidazol‐2‐yl hexafluorostibane; In tetrahydrofuran; at 80 ℃; for 18h; Solvent; Reagent/catalyst; Inert atmosphere;

DOI:10.1021/jo401083m

Reference yield: 37.0%

N-allyl-N-(3-hydroxy-1,3,5-triphenylpent-4-yn-2-yl)-4-methylbenzenesulfonamide → 2-benzyl-2,4-diphenylbut-3-ynal (1448349-80-1)

Guidance literature:

With silver hexafluoroantimonate; In 1,2-dichloro-ethane; at 80 ℃; for 18h; Reagent/catalyst; Inert atmosphere;

DOI:10.1021/jo401083m

Reference yield:

C25H25NO3S → 2-benzyl-2,4-diphenylbut-3-ynal (1448349-80-1)

Guidance literature:

Multi-step reaction with 2 steps

1.1: lithium diisopropyl amide / tetrahydrofuran / 1 h / -78 °C / Inert atmosphere

1.2: 16 h / -78 - 20 °C / Inert atmosphere

2.1: silver hexafluoroantimonate / 1,2-dichloro-ethane / 18 h / 80 °C / Inert atmosphere

With silver hexafluoroantimonate; lithium diisopropyl amide; In tetrahydrofuran; 1,2-dichloro-ethane;

DOI:10.1021/jo401083m

Downstream raw materials:

2,5-dihenyl-3-benzylfuran

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