(Z)-2-(3,5-Dioxo-4-phenyl-[1,2,4]triazolidin-1-yl)-3-hydroxy-but-2-enoic acid ethyl ester

Base Information

• Chemical Name: (Z)-2-(3,5-Dioxo-4-phenyl-[1,2,4]triazolidin-1-yl)-3-hydroxy-but-2-enoic acid ethyl ester
• CAS No.: 67818-00-2
• Molecular Formula: C₁₄H₁₅N₃O₅
• Molecular Weight: 305.29

Synonyms:(Z)-2-(3,5-Dioxo-4-phenyl-[1,2,4]triazolidin-1-yl)-3-hydroxy-but-2-enoic acid ethyl ester

Chemical Property of (Z)-2-(3,5-Dioxo-4-phenyl-[1,2,4]triazolidin-1-yl)-3-hydroxy-but-2-enoic acid ethyl ester

Chemical Property:

Purity/Quality:

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Technology Process of (Z)-2-(3,5-Dioxo-4-phenyl-[1,2,4]triazolidin-1-yl)-3-hydroxy-but-2-enoic acid ethyl ester

There total 3 articles about (Z)-2-(3,5-Dioxo-4-phenyl-[1,2,4]triazolidin-1-yl)-3-hydroxy-but-2-enoic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

ethyl acetoacetate (141-97-9) + dimedone (126-81-8) → (Z)-2-(3,5-Dioxo-4-phenyl-[1,2,4]triazolidin-1-yl)-3-hydroxy-but-2-enoic acid ethyl ester (67818-00-2)

Guidance literature:

trifluoroacetic acid; In dichloromethane; for 1h; Ambient temperature; 25 equiv. ethyl acetoacetate;

DOI:10.1021/jo00288a032

Reference yield: 29.5%

4-Phenyl-1,2,4-triazolidine-3,5-dione (4233-33-4) + ethyl acetoacetate (141-97-9) → (Z)-2-(3,5-Dioxo-4-phenyl-[1,2,4]triazolidin-1-yl)-3-hydroxy-but-2-enoic acid ethyl ester (67818-00-2) + Ethyl 2,2-Bis(4-phenyl-2H-1,2,4-triazoline-3,5-dionyl)-3-oxobutanoate (72708-75-9)

Guidance literature:

trifluoroacetic acid; In dichloromethane; for 4h; Ambient temperature; 3 equiv. ethyl acetoacetate;

DOI:10.1021/jo00288a032

Reference yield:

→ 2-(3,5-dioxo-4-phenyl-[1,2,4]triazolidin-1-yl)-3-oxo-butanoic acid ethyl ester (67818-00-2)

Guidance literature:

entspr. 3-Aminoester (IV), Tos-OH;

upstream raw materials:

4-Phenyl-1,2,4-triazolidine-3,5-dione

ethyl acetoacetate

dimedone

Downstream raw materials:

4-phenyl-2,4,6-triazatricyclo[3.2.1.0(2,6)]dec-8-ene-3,5-dione

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