ethyl 2-(3-nitropyridin-4-yl)-3-oxobutanoate

Base Information

Chemical Name:ethyl 2-(3-nitropyridin-4-yl)-3-oxobutanoate
CAS No.:65645-51-4
Molecular Formula:C₁₁H₁₂N₂O₅
Molecular Weight:252.227
Hs Code.:

Synonyms:ethyl 2-(3-nitropyridin-4-yl)-3-oxobutanoate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of ethyl 2-(3-nitropyridin-4-yl)-3-oxobutanoate

Chemical Property:

Purity/Quality:

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MSDS Files:: SDS file from LookChem

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Technology Process of ethyl 2-(3-nitropyridin-4-yl)-3-oxobutanoate

There total 1 articles about ethyl 2-(3-nitropyridin-4-yl)-3-oxobutanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 5435-54-1
4-hydroxy-3-nitropyridine

: 65645-51-4
ethyl 2-(3-nitropyridin-4-yl)-3-oxobutanoate

Guidance literature:: Multi-step reaction with 2 steps

1.1: N,N-dimethyl-formamide; trichlorophosphate / toluene / 2 h / Inert atmosphere; Reflux

2.1: sodium hydride / N,N-dimethyl-formamide / 1 h / Large scale reaction

2.2: 1.5 h / Large scale reaction

With sodium hydride; N,N-dimethyl-formamide; trichlorophosphate; In N,N-dimethyl-formamide; toluene;
DOI:10.1016/j.tetlet.2011.08.009

Reference yield: 40.5%

: 65645-51-4
ethyl 2-(3-nitropyridin-4-yl)-3-oxobutanoate

: 65645-52-5
ethyl 2-(3-nitro-pyridin-4-yl)acetate

Guidance literature:: With hydrogenchloride; In diethyl ether; ethanol; at 20 ℃; for 72h;
DOI:10.1016/j.tetlet.2011.08.009

Reference yield:

: 65645-51-4
ethyl 2-(3-nitropyridin-4-yl)-3-oxobutanoate

: 65645-57-0
ethyl 2-(3-aminopyridin-4-yl)acetate

Guidance literature:: Multi-step reaction with 2 steps

1: hydrogenchloride / diethyl ether; ethanol / 72 h / 20 °C

2: palladium 10% on activated carbon; hydrogen / ethanol / 16 h / 20 °C / 2250.23 Torr

With hydrogenchloride; palladium 10% on activated carbon; hydrogen; In diethyl ether; ethanol;
DOI:10.1016/j.tetlet.2011.08.009