methyl 2-((6-hydroxy-7-methoxy-1-oxo-3,4-dihydroisoquinolin-2(1H)-yl)sulfonyl)benzoate

Base Information

Chemical Name:methyl 2-((6-hydroxy-7-methoxy-1-oxo-3,4-dihydroisoquinolin-2(1H)-yl)sulfonyl)benzoate
CAS No.:1064206-55-8
Molecular Formula:C₁₈H₁₇NO₇S
Molecular Weight:391.401
Hs Code.:

Synonyms:methyl 2-((6-hydroxy-7-methoxy-1-oxo-3,4-dihydroisoquinolin-2(1H)-yl)sulfonyl)benzoate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of methyl 2-((6-hydroxy-7-methoxy-1-oxo-3,4-dihydroisoquinolin-2(1H)-yl)sulfonyl)benzoate

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Technology Process of methyl 2-((6-hydroxy-7-methoxy-1-oxo-3,4-dihydroisoquinolin-2(1H)-yl)sulfonyl)benzoate

There total 5 articles about methyl 2-((6-hydroxy-7-methoxy-1-oxo-3,4-dihydroisoquinolin-2(1H)-yl)sulfonyl)benzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 10.0%

: methyl 2-((6-benzyloxy-7-methoxy-1-oxo-3,4-dihydroisoquinolin-2(1H)-yl)sulfonyl)benzoate

: 1064206-55-8
methyl 2-((6-hydroxy-7-methoxy-1-oxo-3,4-dihydroisoquinolin-2(1H)-yl)sulfonyl)benzoate

Guidance literature:: With palladium 10% on activated carbon; hydrogen; In tetrahydrofuran; ethanol; at 20 ℃; for 3h;
DOI:10.1002/cmdc.201400017

Reference yield:

: 2107-69-9
5,6-dimethoxy-1-indanone

: 1064206-55-8
methyl 2-((6-hydroxy-7-methoxy-1-oxo-3,4-dihydroisoquinolin-2(1H)-yl)sulfonyl)benzoate

Guidance literature:: Multi-step reaction with 5 steps

1.1: piperidine / water / 192 h / 140 °C

2.1: potassium carbonate / N,N-dimethyl-formamide / 72 h / 20 °C

3.1: methanesulfonic acid; sodium azide / dichloromethane / 16 h / 0 - 20 °C

4.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.5 h / 50 °C

4.2: 6 h / 20 °C

5.1: hydrogen; palladium 10% on activated carbon / tetrahydrofuran; ethanol / 3 h / 20 °C

With piperidine; sodium azide; methanesulfonic acid; palladium 10% on activated carbon; hydrogen; sodium hydride; potassium carbonate; In tetrahydrofuran; ethanol; dichloromethane; water; N,N-dimethyl-formamide; mineral oil;
DOI:10.1002/cmdc.201400017

Reference yield:

: 127399-78-4
5-hydroxy-6-methoxy-2,3-dihydro-1H-inden-1-one

: 1064206-55-8
methyl 2-((6-hydroxy-7-methoxy-1-oxo-3,4-dihydroisoquinolin-2(1H)-yl)sulfonyl)benzoate

Guidance literature:: Multi-step reaction with 4 steps

1.1: potassium carbonate / N,N-dimethyl-formamide / 72 h / 20 °C

2.1: methanesulfonic acid; sodium azide / dichloromethane / 16 h / 0 - 20 °C

3.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.5 h / 50 °C

3.2: 6 h / 20 °C

4.1: hydrogen; palladium 10% on activated carbon / tetrahydrofuran; ethanol / 3 h / 20 °C

With sodium azide; methanesulfonic acid; palladium 10% on activated carbon; hydrogen; sodium hydride; potassium carbonate; In tetrahydrofuran; ethanol; dichloromethane; N,N-dimethyl-formamide; mineral oil;
DOI:10.1002/cmdc.201400017