(2'R)-2-<<<2'-Benzyl-2',4'-bis<(benzyloxycarbonyl)amino>-1'-oxobutyl>amino>methyl>-1,3-dithiane

Base Information

Chemical Name:(2'R)-2-<<<2'-Benzyl-2',4'-bis<(benzyloxycarbonyl)amino>-1'-oxobutyl>amino>methyl>-1,3-dithiane
CAS No.:159801-79-3
Molecular Formula:C₃₂H₃₇N₃O₅S₂
Molecular Weight:607.795
Hs Code.:

Synonyms:(2'R)-2-<<<2'-Benzyl-2',4'-bis<(benzyloxycarbonyl)amino>-1'-oxobutyl>amino>methyl>-1,3-dithiane

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Chemical Property of (2'R)-2-<<<2'-Benzyl-2',4'-bis<(benzyloxycarbonyl)amino>-1'-oxobutyl>amino>methyl>-1,3-dithiane

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Technology Process of (2'R)-2-<<<2'-Benzyl-2',4'-bis<(benzyloxycarbonyl)amino>-1'-oxobutyl>amino>methyl>-1,3-dithiane

There total 9 articles about (2'R)-2-<<<2'-Benzyl-2',4'-bis<(benzyloxycarbonyl)amino>-1'-oxobutyl>amino>methyl>-1,3-dithiane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

: 2-(2-Aminomethyl)-1,3-dithiane trifluoroacetic acid salt

: 159801-77-1
(2R)-2-Benzyl-2,4-bis<(benzyloxycarbonyl)amino>butyric acid

: 159801-79-3
(2'R)-2-<<<2'-Benzyl-2',4'-bis<(benzyloxycarbonyl)amino>-1'-oxobutyl>amino>methyl>-1,3-dithiane

Guidance literature:: With diphenyl-phosphinic acid; triethylamine; In N,N-dimethyl-formamide; at 0 ℃; for 6h;
DOI:10.1021/jo00104a022

Reference yield:

: 95260-60-9
(2S,4S)-benzyl 4-benzyl-5-oxo-2-phenyloxazolidine-3-carboxylate

: 159801-79-3
(2'R)-2-<<<2'-Benzyl-2',4'-bis<(benzyloxycarbonyl)amino>-1'-oxobutyl>amino>methyl>-1,3-dithiane

Guidance literature:: Multi-step reaction with 9 steps

1: 1.) KN(TMS)2, 2.) BF₃*Et₂O / 1.) THF, -78 deg C, 15 min, 2.) -78 deg C, 1.5 h

2: 88 percent / pyridine / CH₂Cl₂ / 48 h / 20 °C

3: 93 percent / NaN₃ / dimethylformamide / 20 h / 40 °C

4: 1 M aq. NaOH / methanol / 48 h / 20 °C

5: H₂, 2 M aq. HCl / 10percent Pd/C / ethanol / 2 h / 20 °C / 2844.3 Torr

6: dioxane / 4 h / 55 °C

7: Et₃N / dioxane / 35 °C

8: 1 N aq. HCl / methanol; dioxane

9: 72 percent / DPPA, Et₃N / dimethylformamide / 6 h / 0 °C

With pyridine; hydrogenchloride; sodium hydroxide; sodium azide; boron trifluoride diethyl etherate; diphenyl-phosphinic acid; hydrogen; potassium hexamethylsilazane; triethylamine; palladium on activated charcoal; In 1,4-dioxane; methanol; ethanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jo00104a022

Reference yield:

: (R)-2-Amino-4-azido-2-benzyl-butyric acid

: 159801-79-3
(2'R)-2-<<<2'-Benzyl-2',4'-bis<(benzyloxycarbonyl)amino>-1'-oxobutyl>amino>methyl>-1,3-dithiane

Guidance literature:: Multi-step reaction with 5 steps

1: H₂, 2 M aq. HCl / 10percent Pd/C / ethanol / 2 h / 20 °C / 2844.3 Torr

2: dioxane / 4 h / 55 °C

3: Et₃N / dioxane / 35 °C

4: 1 N aq. HCl / methanol; dioxane

5: 72 percent / DPPA, Et₃N / dimethylformamide / 6 h / 0 °C

With hydrogenchloride; diphenyl-phosphinic acid; hydrogen; triethylamine; palladium on activated charcoal; In 1,4-dioxane; methanol; ethanol; N,N-dimethyl-formamide;
DOI:10.1021/jo00104a022