8-[(4-amino-1-methyl)-butyl]-amino-6-methoxy-5-(3-methoxyphenyl)-4-methyl-2-trifluoromethyl-quinoline

Base Information

Chemical Name:8-[(4-amino-1-methyl)-butyl]-amino-6-methoxy-5-(3-methoxyphenyl)-4-methyl-2-trifluoromethyl-quinoline
CAS No.:1260253-59-5
Molecular Formula:C₂₄H₂₈F₃N₃O₂
Molecular Weight:447.5
Hs Code.:

Synonyms:8-[(4-amino-1-methyl)-butyl]-amino-6-methoxy-5-(3-methoxyphenyl)-4-methyl-2-trifluoromethyl-quinoline

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Chemical Property of 8-[(4-amino-1-methyl)-butyl]-amino-6-methoxy-5-(3-methoxyphenyl)-4-methyl-2-trifluoromethyl-quinoline

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Technology Process of 8-[(4-amino-1-methyl)-butyl]-amino-6-methoxy-5-(3-methoxyphenyl)-4-methyl-2-trifluoromethyl-quinoline

There total 8 articles about 8-[(4-amino-1-methyl)-butyl]-amino-6-methoxy-5-(3-methoxyphenyl)-4-methyl-2-trifluoromethyl-quinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

: 1260253-94-8
8-[(1-methyl-4-phthalimido)-butyl]-amino-6-methoxy-5-(3-methoxy)-phenyl-4-methyl-2-trifluoromethyl-quinoline

: 1260253-59-5
8-[(4-amino-1-methyl)-butyl]-amino-6-methoxy-5-(3-methoxyphenyl)-4-methyl-2-trifluoromethyl-quinoline

Guidance literature:: With hydrazine hydrate; In ethanol; Reflux; Inert atmosphere;
DOI:10.1021/jm100911f

Reference yield:

: 1260253-74-4
6-methoxy-5-(3-methoxyphenyl)-4-methyl-8-nitro-2-trifluoromethyl-quinoline

: 1260253-59-5
8-[(4-amino-1-methyl)-butyl]-amino-6-methoxy-5-(3-methoxyphenyl)-4-methyl-2-trifluoromethyl-quinoline

Guidance literature:: Multi-step reaction with 3 steps

1: 10% palladium on activated carbon; hydrogen / ethyl acetate

2: borane pyridine; acetic acid / 20 °C / Inert atmosphere

3: hydrazine hydrate / ethanol / Reflux; Inert atmosphere

With borane pyridine; 10% palladium on activated carbon; hydrogen; hydrazine hydrate; acetic acid; In ethanol; ethyl acetate;
DOI:10.1021/jm100911f

Reference yield:

: 1260253-84-6
8-amino-6-methoxy-5-(3-methoxyphenyl)-4-methyl-2-trifluoromethyl-quinoline

: 1260253-59-5
8-[(4-amino-1-methyl)-butyl]-amino-6-methoxy-5-(3-methoxyphenyl)-4-methyl-2-trifluoromethyl-quinoline

Guidance literature:: Multi-step reaction with 2 steps

1: borane pyridine; acetic acid / 20 °C / Inert atmosphere

2: hydrazine hydrate / ethanol / Reflux; Inert atmosphere

With borane pyridine; hydrazine hydrate; acetic acid; In ethanol;
DOI:10.1021/jm100911f