1-(benzyloxy)-2,4-dichloro-6-<3-(1-fluorophenyl)-3-(tosyloxy)-1-propyl>benzene

Base Information

Chemical Name:1-(benzyloxy)-2,4-dichloro-6-<3-(1-fluorophenyl)-3-(tosyloxy)-1-propyl>benzene
CAS No.:136007-77-7
Molecular Formula:C₂₉H₂₅Cl₂FO₄S
Molecular Weight:559.486
Hs Code.:

Synonyms:1-(benzyloxy)-2,4-dichloro-6-<3-(1-fluorophenyl)-3-(tosyloxy)-1-propyl>benzene

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 1-(benzyloxy)-2,4-dichloro-6-<3-(1-fluorophenyl)-3-(tosyloxy)-1-propyl>benzene

Chemical Property:

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Technology Process of 1-(benzyloxy)-2,4-dichloro-6-<3-(1-fluorophenyl)-3-(tosyloxy)-1-propyl>benzene

There total 8 articles about 1-(benzyloxy)-2,4-dichloro-6-<3-(1-fluorophenyl)-3-(tosyloxy)-1-propyl>benzene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

: 136007-76-6
1-(benzyloxy)-2,4-dichloro-6-<3-(1-fluorophenyl)-3-hydroxypropyl>benzene

: 98-59-9
p-toluenesulfonyl chloride

: 136007-77-7
1-(benzyloxy)-2,4-dichloro-6-<3-(1-fluorophenyl)-3-(tosyloxy)-1-propyl>benzene

Guidance literature:: With pyridine; In dichloromethane; at 20 ℃; for 6h;
DOI:10.1021/jm00114a004

Reference yield:

: 6992-87-6
1-(4-fluorophenyl)-3-bromoprop-1-ene

: 136007-77-7
1-(benzyloxy)-2,4-dichloro-6-<3-(1-fluorophenyl)-3-(tosyloxy)-1-propyl>benzene

Guidance literature:: Multi-step reaction with 5 steps

1: 79 percent / K₂CO₃ / acetone / 4 h / Heating

2: 84 percent / N,N-dimethylaniline / bis-(2-methoxy-ethyl) ether / 10 h / 160 °C

3: K₂CO₃ / dimethylformamide / 8 h / 70 - 75 °C

4: 1.) 9-BBN, 2.) 2N aq. NaOH, H₂O₂ / 1.) THF, a) 20 deg C, 30 min, b) reflux, 90 min, 2.) THF, reflux, 1 h

5: 91 percent / pyridine / CH₂Cl₂ / 6 h / 20 °C

With pyridine; sodium hydroxide; 9-borabicyclo[3.3.1]nonane dimer; dihydrogen peroxide; potassium carbonate; N,N-dimethyl-aniline; In dichloromethane; diethylene glycol dimethyl ether; N,N-dimethyl-formamide; acetone;
DOI:10.1021/jm00114a004

Reference yield:

: 100-44-7
benzyl chloride

: 136007-77-7
1-(benzyloxy)-2,4-dichloro-6-<3-(1-fluorophenyl)-3-(tosyloxy)-1-propyl>benzene

Guidance literature:: Multi-step reaction with 3 steps

1: K₂CO₃ / dimethylformamide / 8 h / 70 - 75 °C

2: 1.) 9-BBN, 2.) 2N aq. NaOH, H₂O₂ / 1.) THF, a) 20 deg C, 30 min, b) reflux, 90 min, 2.) THF, reflux, 1 h

3: 91 percent / pyridine / CH₂Cl₂ / 6 h / 20 °C

With pyridine; sodium hydroxide; 9-borabicyclo[3.3.1]nonane dimer; dihydrogen peroxide; potassium carbonate; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm00114a004