methyl (1α,3α,4β)-4-[(tert-butoxycarbonyl)amino]-3-hydroxycyclohexanecarboxylate

Base Information

Chemical Name:methyl (1α,3α,4β)-4-[(tert-butoxycarbonyl)amino]-3-hydroxycyclohexanecarboxylate
CAS No.:615569-02-3
Molecular Formula:C₁₃H₂₃NO₅
Molecular Weight:273.329
Hs Code.:

Synonyms:methyl (1α,3α,4β)-4-[(tert-butoxycarbonyl)amino]-3-hydroxycyclohexanecarboxylate

Suppliers and Price of methyl (1α,3α,4β)-4-[(tert-butoxycarbonyl)amino]-3-hydroxycyclohexanecarboxylate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of methyl (1α,3α,4β)-4-[(tert-butoxycarbonyl)amino]-3-hydroxycyclohexanecarboxylate

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of methyl (1α,3α,4β)-4-[(tert-butoxycarbonyl)amino]-3-hydroxycyclohexanecarboxylate

There total 4 articles about methyl (1α,3α,4β)-4-[(tert-butoxycarbonyl)amino]-3-hydroxycyclohexanecarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 643070-24-0
(1R,3R,4R)-4-azido-3-hydroxy-cyclohexanecarboxylic acid methyl ester

: 615569-02-3
methyl (1α,3α,4β)-4-[(tert-butoxycarbonyl)amino]-3-hydroxycyclohexanecarboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: palladium on activated charcoal; hydrogen / methanol; acetic acid / 18 h / 20 °C / 760.05 Torr

2: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 18 h / 50 °C

With palladium on activated charcoal; hydrogen; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; methanol; acetic acid;
DOI:10.1016/j.bmcl.2011.09.114

Reference yield:

: 643068-20-6
(1R,4S,5R)-4-bromo-6-oxabicyclo[3.2.1]octan-7-one

: 615569-02-3
methyl (1α,3α,4β)-4-[(tert-butoxycarbonyl)amino]-3-hydroxycyclohexanecarboxylate

Guidance literature:: Multi-step reaction with 4 steps

1: sodium hydrogencarbonate / 18 h

2: sodium azide / N,N-dimethyl-formamide / 8 h / 60 °C

3: palladium on activated charcoal; hydrogen / methanol; acetic acid / 18 h / 20 °C / 760.05 Torr

4: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 18 h / 50 °C

With sodium azide; palladium on activated charcoal; hydrogen; sodium hydrogencarbonate; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; methanol; acetic acid; N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2011.09.114

Reference yield:

: 5709-98-8
(R)-cyclohex-3-enecarboxylic acid

: 615569-02-3
methyl (1α,3α,4β)-4-[(tert-butoxycarbonyl)amino]-3-hydroxycyclohexanecarboxylate

Guidance literature:: Multi-step reaction with 5 steps

1: trimethylsilyl bromide; N-ethyl-N,N-diisopropylamine / dimethyl sulfoxide

2: sodium hydrogencarbonate / 18 h

3: sodium azide / N,N-dimethyl-formamide / 8 h / 60 °C

4: palladium on activated charcoal; hydrogen / methanol; acetic acid / 18 h / 20 °C / 760.05 Torr

5: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 18 h / 50 °C

With sodium azide; trimethylsilyl bromide; palladium on activated charcoal; hydrogen; sodium hydrogencarbonate; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; methanol; acetic acid; dimethyl sulfoxide; N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2011.09.114