1-tert-butyl 2-methyl 5-hydroxy-4-(2-hydroxy-4-methoxybenzyl)-5,6-dihydropyrazine-1,2(4H)-dicarboxylate

Base Information

Chemical Name:1-tert-butyl 2-methyl 5-hydroxy-4-(2-hydroxy-4-methoxybenzyl)-5,6-dihydropyrazine-1,2(4H)-dicarboxylate
CAS No.:1355024-87-1
Molecular Formula:C₁₉H₂₆N₂O₇
Molecular Weight:394.425
Hs Code.:

Synonyms:1-tert-butyl 2-methyl 5-hydroxy-4-(2-hydroxy-4-methoxybenzyl)-5,6-dihydropyrazine-1,2(4H)-dicarboxylate

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Chemical Property of 1-tert-butyl 2-methyl 5-hydroxy-4-(2-hydroxy-4-methoxybenzyl)-5,6-dihydropyrazine-1,2(4H)-dicarboxylate

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Technology Process of 1-tert-butyl 2-methyl 5-hydroxy-4-(2-hydroxy-4-methoxybenzyl)-5,6-dihydropyrazine-1,2(4H)-dicarboxylate

There total 3 articles about 1-tert-butyl 2-methyl 5-hydroxy-4-(2-hydroxy-4-methoxybenzyl)-5,6-dihydropyrazine-1,2(4H)-dicarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

: 164515-08-6
2-(aminomethyl)-5-methoxyphenol

: 943818-65-3
4-(tert-butoxycarbonyl)-3-methoxycarbonyl-4H-[1,4]oxazine

: 1355024-87-1
1-tert-butyl 2-methyl 5-hydroxy-4-(2-hydroxy-4-methoxybenzyl)-5,6-dihydropyrazine-1,2(4H)-dicarboxylate

Guidance literature:: With potassium carbonate; In acetonitrile; at 20 ℃; for 24h; Inert atmosphere;
DOI:10.1021/ol203364b

Reference yield:

: 17861-16-4
2-hydroxy-4-methoxybenzaldehyde oxime

: 1355024-87-1
1-tert-butyl 2-methyl 5-hydroxy-4-(2-hydroxy-4-methoxybenzyl)-5,6-dihydropyrazine-1,2(4H)-dicarboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: hydrogenchloride; 5%-palladium/activated carbon; hydrogen / ethanol; water / 12 h / 760.05 Torr

2: potassium carbonate / acetonitrile / 24 h / 20 °C / Inert atmosphere

With hydrogenchloride; 5%-palladium/activated carbon; hydrogen; potassium carbonate; In ethanol; water; acetonitrile; 2: Michael addition;
DOI:10.1021/ol203364b

Reference yield:

: 673-22-3
2-Hydroxy-4-methoxybenzaldehyde

: 1355024-87-1
1-tert-butyl 2-methyl 5-hydroxy-4-(2-hydroxy-4-methoxybenzyl)-5,6-dihydropyrazine-1,2(4H)-dicarboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: hydroxylamine hydrochloride; sodium hydroxide / ethanol; water / 0 - 20 °C

2: hydrogenchloride; 5%-palladium/activated carbon; hydrogen / ethanol; water / 12 h / 760.05 Torr

3: potassium carbonate / acetonitrile / 24 h / 20 °C / Inert atmosphere

With hydrogenchloride; 5%-palladium/activated carbon; hydroxylamine hydrochloride; hydrogen; potassium carbonate; sodium hydroxide; In ethanol; water; acetonitrile; 3: Michael addition;
DOI:10.1021/ol203364b