(R)-1-PHOSPHONO-BENZYLAMINE

Base Information

• Chemical Name: (R)-1-PHOSPHONO-BENZYLAMINE
• CAS No.: 37714-05-9
• Molecular Formula: C7H10 N O3 P
• Molecular Weight: 187.135
• Hs Code.: 2931900090
• Mol file: 37714-05-9.mol

Synonyms:Phosphonicacid, (aminophenylmethyl)-, (R)-; Phosphonic acid, [(R)-aminophenylmethyl]-(9CI); ((R)-a-Aminobenzyl)phosphonicacid; (+)-a-Aminobenzylphosphonic acid;(R)-(Amino(phenyl)methyl)phosphonic acid; (R)-Phosphophenylglycine

Chemical Property of (R)-1-PHOSPHONO-BENZYLAMINE

Chemical Property:

• PSA: 93.36000
• LogP: 1.52190

Purity/Quality:

98% ^*data from raw suppliers

(R)-1-AMINO-BENZYLPHOSPHONIC ACID 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (R)-1-PHOSPHONO-BENZYLAMINE

There total 50 articles about (R)-1-PHOSPHONO-BENZYLAMINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

C18H22NO4P (1201762-38-0) → (R)-1-amino-1-phenylmethylphosphonic acid (37714-05-9)

Guidance literature:

C₁₈H₂₂NO₄P; With hydrogenchloride; water; for 16h; Inert atmosphere; Reflux;

With methyloxirane; In ethanol; at 20 ℃; for 3h; Inert atmosphere;

DOI:10.1002/chem.200901901

Reference yield: 95.0%

(RS)-(-)-N-p-toluenesulfinyl-1-amino-1-phenylmethyl-bis(diethylamino)phosphine borane → (R)-1-amino-1-phenylmethylphosphonic acid (37714-05-9)

Guidance literature:

With hydrogenchloride; acetic acid; In water; for 4h; Heating;

DOI:10.1016/S0957-4166(02)00684-5

Reference yield: 91.0%

C23H21F6NO4P2 (1045892-73-6) → (R)-1-amino-1-phenylmethylphosphonic acid (37714-05-9)

Guidance literature:

With hydrogenchloride; water; In methanol; at 95 ℃; for 12h; Inert atmosphere;

DOI:10.1021/ja803859p

upstream raw materials:

D-1-(N-Phenylacetylamino)-1-phenylmethylphosphonic acid

1-amino-1-phenylmethylphosphonic acid

1-(N-Phenylacetylamino)-1-phenylmethylphosphonic acid

N - ((R)-α-methylbenzyl)amino(phenyl)methylphosphonic acid

Downstream raw materials:

(R)-1-benzyloxycarbonylamino-1-phenylmethylphosphonic acid

Refernces

• 1、 Hamilton, Robert,Walker, Brian,Walker, Brian J.. "A Highly Convenient Route to Optically Pure α-Aminophosphonic Acids". . p. 4451 - 4454. Retrieved 1995.
• 2、 Glowiak,T. et al.. "-". . p. 3965 - 3968. Retrieved 1977.
• 3、 Lyzwa, Piotr. "Double asymmetric induction in the synthesis of enantiomeric α-aminophosphonic acids mediated by sulfinimines". . p. 15 - 19. Retrieved 2014/02/14.
• 4、 Metlushka, Kirill E.,Kashemirov, Boris A.,Zheltukhin, Viktor F.,Sadkova, Dilyara N.,Buechner, Bernd,Hess, Christian,Kataeva, Olga N.,McKenna, Charles E.,Alfonsov, Vladimir A.. "1-(a-Aminobenzyl)-2-naphthol: A new chiral auxiliary for the synthesis of enantiopure a-aminophosphonic acids". supporting information; experimental part. p. 6718 - 6722. Retrieved 2010/02/28.