dimethyl (R)-4-(tert-butyldiphenylsilyloxy)-5-(4-methoxybenzyloxy)-2-oxopentylphosphonate

Base Information

Chemical Name:dimethyl (R)-4-(tert-butyldiphenylsilyloxy)-5-(4-methoxybenzyloxy)-2-oxopentylphosphonate
CAS No.:1453486-57-1
Molecular Formula:C₃₁H₄₁O₇PSi
Molecular Weight:584.722
Hs Code.:

Synonyms:dimethyl (R)-4-(tert-butyldiphenylsilyloxy)-5-(4-methoxybenzyloxy)-2-oxopentylphosphonate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of dimethyl (R)-4-(tert-butyldiphenylsilyloxy)-5-(4-methoxybenzyloxy)-2-oxopentylphosphonate

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Technology Process of dimethyl (R)-4-(tert-butyldiphenylsilyloxy)-5-(4-methoxybenzyloxy)-2-oxopentylphosphonate

There total 2 articles about dimethyl (R)-4-(tert-butyldiphenylsilyloxy)-5-(4-methoxybenzyloxy)-2-oxopentylphosphonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

: 1453486-56-0
methyl (R)-3-(tert-butyldiphenylsilyloxy)-4-(4-methoxybenzyloxy)butanoate

: 756-79-6
dimethyl methane phosphonate

: 1453486-57-1
dimethyl (R)-4-(tert-butyldiphenylsilyloxy)-5-(4-methoxybenzyloxy)-2-oxopentylphosphonate

Guidance literature:: dimethyl methane phosphonate; With n-butyllithium; In tetrahydrofuran; hexane; at -78 ℃; for 0.75h; Inert atmosphere;

methyl (R)-3-(tert-butyldiphenylsilyloxy)-4-(4-methoxybenzyloxy)butanoate; In tetrahydrofuran; hexane; for 1.5h; Inert atmosphere;
DOI:10.1016/j.tetasy.2013.07.002

Reference yield:

: 1453486-55-9
methyl (R)-3-hydroxy-4-(4-methoxybenzyloxy)butanoate

: 1453486-57-1
dimethyl (R)-4-(tert-butyldiphenylsilyloxy)-5-(4-methoxybenzyloxy)-2-oxopentylphosphonate

Guidance literature:: Multi-step reaction with 2 steps

1.1: 1H-imidazole / N,N-dimethyl-formamide / 0.17 h / Inert atmosphere

1.2: 6 h / 20 °C / Inert atmosphere

2.1: n-butyllithium / tetrahydrofuran; hexane / 0.75 h / -78 °C / Inert atmosphere

2.2: 1.5 h / Inert atmosphere

With 1H-imidazole; n-butyllithium; In tetrahydrofuran; hexane; N,N-dimethyl-formamide;
DOI:10.1016/j.tetasy.2013.07.002

Reference yield:

: 1453486-57-1
dimethyl (R)-4-(tert-butyldiphenylsilyloxy)-5-(4-methoxybenzyloxy)-2-oxopentylphosphonate

: 1453486-60-6
C₁₆H₂₆O₃

: 1453486-61-7
(2R,5E,9Z,12Z)-2-((tert-butyldiphenylsilyl)oxy)-1-((4-methoxybenzyl)oxy)-9,12-dimethyl-14-((tetrahydro-2H-pyran-2-yl)oxy)tetradeca-5,9,12-trien-4-one

Guidance literature:: With barium hydroxide octahydrate; In tetrahydrofuran; water; at 20 ℃; for 2h; Inert atmosphere;
DOI:10.1016/j.tetasy.2013.07.002