1-(5,6-dihydroxy-3,4-dihydroisoquinolin-2(1H)-yl)-4-(2,5-dihydroxyyphenyl)butan-1-one

Base Information

Chemical Name:1-(5,6-dihydroxy-3,4-dihydroisoquinolin-2(1H)-yl)-4-(2,5-dihydroxyyphenyl)butan-1-one
CAS No.:1326317-05-8
Molecular Formula:C₁₉H₂₁NO₅
Molecular Weight:343.379
Hs Code.:

Synonyms:1-(5,6-dihydroxy-3,4-dihydroisoquinolin-2(1H)-yl)-4-(2,5-dihydroxyyphenyl)butan-1-one

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Chemical Property of 1-(5,6-dihydroxy-3,4-dihydroisoquinolin-2(1H)-yl)-4-(2,5-dihydroxyyphenyl)butan-1-one

Chemical Property:

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Technology Process of 1-(5,6-dihydroxy-3,4-dihydroisoquinolin-2(1H)-yl)-4-(2,5-dihydroxyyphenyl)butan-1-one

There total 4 articles about 1-(5,6-dihydroxy-3,4-dihydroisoquinolin-2(1H)-yl)-4-(2,5-dihydroxyyphenyl)butan-1-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1326317-03-6
1-(5,6-dimethoxy-3,4-dihydroisoquinolin-2(1H)-yl)-4-(2,5-dimethoxyphenyl)butan-1-one

: 1326317-05-8
1-(5,6-dihydroxy-3,4-dihydroisoquinolin-2(1H)-yl)-4-(2,5-dihydroxyyphenyl)butan-1-one

Guidance literature:: 1-(5,6-dimethoxy-3,4-dihydroisoquinolin-2(1H)-yl)-4-(2,5-dimethoxyphenyl)butan-1-one; With boron tribromide; In dichloromethane; at -78 - 20 ℃; Inert atmosphere;

With methanol; In dichloromethane; water; at 0 ℃; for 0.166667h; Inert atmosphere;
DOI:10.1021/jm2008387

Reference yield:

: 52759-09-8
5,6-dimethoxy-1,2,3,4-tetrahydro-isoquinoline

: 1326317-05-8
1-(5,6-dihydroxy-3,4-dihydroisoquinolin-2(1H)-yl)-4-(2,5-dihydroxyyphenyl)butan-1-one

Guidance literature:: Multi-step reaction with 2 steps

1.1: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 20 °C / Inert atmosphere

2.1: boron tribromide / dichloromethane / -78 - 20 °C / Inert atmosphere

2.2: 0.17 h / 0 °C / Inert atmosphere

With dmap; boron tribromide; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane;
DOI:10.1021/jm2008387

Reference yield:

: 3213-29-4
2,3-dimethoxyphenethylamine

: 1326317-05-8
1-(5,6-dihydroxy-3,4-dihydroisoquinolin-2(1H)-yl)-4-(2,5-dihydroxyyphenyl)butan-1-one

Guidance literature:: Multi-step reaction with 3 steps

1.1: trifluoroacetic acid / dichloromethane; water / 5.25 h / 20 °C

2.1: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 20 °C / Inert atmosphere

3.1: boron tribromide / dichloromethane / -78 - 20 °C / Inert atmosphere

3.2: 0.17 h / 0 °C / Inert atmosphere

With dmap; boron tribromide; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; trifluoroacetic acid; In dichloromethane; water; 1.1: Pictet-Spengler cyclisation;
DOI:10.1021/jm2008387