(S)-2-[4-(2-Methyl-4-oxo-3,4-dihydro-quinazolin-6-ylmethoxy)-benzoylamino]-pentanedioic acid diethyl ester

Base Information

Chemical Name:(S)-2-[4-(2-Methyl-4-oxo-3,4-dihydro-quinazolin-6-ylmethoxy)-benzoylamino]-pentanedioic acid diethyl ester
CAS No.:133447-15-1
Molecular Formula:C₂₆H₂₉N₃O₇
Molecular Weight:495.532
Hs Code.:

Synonyms:(S)-2-[4-(2-Methyl-4-oxo-3,4-dihydro-quinazolin-6-ylmethoxy)-benzoylamino]-pentanedioic acid diethyl ester

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Chemical Property of (S)-2-[4-(2-Methyl-4-oxo-3,4-dihydro-quinazolin-6-ylmethoxy)-benzoylamino]-pentanedioic acid diethyl ester

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Technology Process of (S)-2-[4-(2-Methyl-4-oxo-3,4-dihydro-quinazolin-6-ylmethoxy)-benzoylamino]-pentanedioic acid diethyl ester

There total 2 articles about (S)-2-[4-(2-Methyl-4-oxo-3,4-dihydro-quinazolin-6-ylmethoxy)-benzoylamino]-pentanedioic acid diethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 133446-87-4
4-(2-Methyl-4-oxo-3,4-dihydro-quinazolin-6-ylmethoxy)-benzoic acid methyl ester

: 133447-15-1
(S)-2-[4-(2-Methyl-4-oxo-3,4-dihydro-quinazolin-6-ylmethoxy)-benzoylamino]-pentanedioic acid diethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 81 percent / 1 N aq. NaOH / ethanol / 0.5 h / 52 °C

2: 72 percent / diphenyl phosphorazidate (DPPA), Et₃N / dimethylformamide / 16 h / Ambient temperature

With sodium hydroxide; diphenyl phosphoryl azide; triethylamine; In ethanol; N,N-dimethyl-formamide;
DOI:10.1021/jm00111a042

Reference yield:

: 99-76-3,156291-94-0
methyl 4-hydroxylbenzoate

: 133447-15-1
(S)-2-[4-(2-Methyl-4-oxo-3,4-dihydro-quinazolin-6-ylmethoxy)-benzoylamino]-pentanedioic acid diethyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 5 percent / CaCO₃, K₂CO₃ / N,N-dimethyl-acetamide / 5 h / 100 °C

2: 81 percent / 1 N aq. NaOH / ethanol / 0.5 h / 52 °C

3: 72 percent / diphenyl phosphorazidate (DPPA), Et₃N / dimethylformamide / 16 h / Ambient temperature

With sodium hydroxide; diphenyl phosphoryl azide; potassium carbonate; triethylamine; calcium carbonate; In ethanol; N,N-dimethyl acetamide; N,N-dimethyl-formamide;
DOI:10.1021/jm00111a042