Bromomethyl-[(R)-1-((2R,4aR,6S,8aS)-6-methoxy-2-phenyl-4,4a,6,8a-tetrahydro-pyrano[3,2-d][1,3]dioxin-7-yl)-propoxy]-dimethyl-silane

Base Information

Chemical Name:Bromomethyl-[(R)-1-((2R,4aR,6S,8aS)-6-methoxy-2-phenyl-4,4a,6,8a-tetrahydro-pyrano[3,2-d][1,3]dioxin-7-yl)-propoxy]-dimethyl-silane
CAS No.:161821-35-8
Molecular Formula:C₂₀H₂₉BrO₅Si
Molecular Weight:457.437
Hs Code.:

Synonyms:Bromomethyl-[(R)-1-((2R,4aR,6S,8aS)-6-methoxy-2-phenyl-4,4a,6,8a-tetrahydro-pyrano[3,2-d][1,3]dioxin-7-yl)-propoxy]-dimethyl-silane

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Chemical Property of Bromomethyl-[(R)-1-((2R,4aR,6S,8aS)-6-methoxy-2-phenyl-4,4a,6,8a-tetrahydro-pyrano[3,2-d][1,3]dioxin-7-yl)-propoxy]-dimethyl-silane

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Technology Process of Bromomethyl-[(R)-1-((2R,4aR,6S,8aS)-6-methoxy-2-phenyl-4,4a,6,8a-tetrahydro-pyrano[3,2-d][1,3]dioxin-7-yl)-propoxy]-dimethyl-silane

There total 4 articles about Bromomethyl-[(R)-1-((2R,4aR,6S,8aS)-6-methoxy-2-phenyl-4,4a,6,8a-tetrahydro-pyrano[3,2-d][1,3]dioxin-7-yl)-propoxy]-dimethyl-silane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 114047-68-6
(2R,4aR,6S,8aR)-6-Methoxy-2-phenyl-7-prop-(E)-ylidene-tetrahydro-pyrano[3,2-d][1,3]dioxin-8-one

: 161821-35-8
Bromomethyl-[(R)-1-((2R,4aR,6S,8aS)-6-methoxy-2-phenyl-4,4a,6,8a-tetrahydro-pyrano[3,2-d][1,3]dioxin-7-yl)-propoxy]-dimethyl-silane

Guidance literature:: Multi-step reaction with 4 steps

1: 73 percent / NaBH₄, CeCl₃ / ethanol

2: PPh₃, DEAD / toluene

3: NH₃ / methanol

4: Et₃N / CH₂Cl₂

With sodium tetrahydroborate; cerium(III) chloride; ammonia; triethylamine; triphenylphosphine; diethylazodicarboxylate; In methanol; ethanol; dichloromethane; toluene;
DOI:10.1016/S0040-4039(00)73076-0

Reference yield:

: 161821-24-5
(2R,4aR,6S,8R,8aS)-6-Methoxy-2-phenyl-7-prop-(Z)-ylidene-hexahydro-pyrano[3,2-d][1,3]dioxin-8-ol

: 161821-35-8
Bromomethyl-[(R)-1-((2R,4aR,6S,8aS)-6-methoxy-2-phenyl-4,4a,6,8a-tetrahydro-pyrano[3,2-d][1,3]dioxin-7-yl)-propoxy]-dimethyl-silane

Guidance literature:: Multi-step reaction with 3 steps

1: PPh₃, DEAD / toluene

2: NH₃ / methanol

3: Et₃N / CH₂Cl₂

With ammonia; triethylamine; triphenylphosphine; diethylazodicarboxylate; In methanol; dichloromethane; toluene;
DOI:10.1016/S0040-4039(00)73076-0

Reference yield:

: 161821-27-8
Chloro-acetic acid (R)-1-((2R,4aR,6S,8aS)-6-methoxy-2-phenyl-4,4a,6,8a-tetrahydro-pyrano[3,2-d][1,3]dioxin-7-yl)-propyl ester

: 161821-35-8
Bromomethyl-[(R)-1-((2R,4aR,6S,8aS)-6-methoxy-2-phenyl-4,4a,6,8a-tetrahydro-pyrano[3,2-d][1,3]dioxin-7-yl)-propoxy]-dimethyl-silane

Guidance literature:: Multi-step reaction with 2 steps

1: NH₃ / methanol

2: Et₃N / CH₂Cl₂

With ammonia; triethylamine; In methanol; dichloromethane;
DOI:10.1016/S0040-4039(00)73076-0