ethyl {1-[5-(3-fluoro-4-formylphenyl)pyrimidin-2-yl]piperidin-4-yl}acetate

Base Information

• Chemical Name: ethyl {1-[5-(3-fluoro-4-formylphenyl)pyrimidin-2-yl]piperidin-4-yl}acetate
• CAS No.: 1388144-32-8
• Molecular Formula: C₂₀H₂₂FN₃O₃
• Molecular Weight: 371.411
• Mol file: 1388144-32-8.mol

Synonyms:ethyl {1-[5-(3-fluoro-4-formylphenyl)pyrimidin-2-yl]piperidin-4-yl}acetate

Chemical Property of ethyl {1-[5-(3-fluoro-4-formylphenyl)pyrimidin-2-yl]piperidin-4-yl}acetate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of ethyl {1-[5-(3-fluoro-4-formylphenyl)pyrimidin-2-yl]piperidin-4-yl}acetate

There total 3 articles about ethyl {1-[5-(3-fluoro-4-formylphenyl)pyrimidin-2-yl]piperidin-4-yl}acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

ethyl (piperidin-4-yl)acetate (59184-90-6) → ethyl {1-[5-(3-fluoro-4-formylphenyl)pyrimidin-2-yl]piperidin-4-yl}acetate (1388144-32-8)

Guidance literature:

Multi-step reaction with 3 steps

1: caesium carbonate / N,N-dimethyl-formamide / 18 h / 50 °C

2: potassium acetate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / dimethyl sulfoxide / 18 h / 100 °C / Inert atmosphere

3: sodium carbonate / 1,2-dimethoxyethane; ethanol / 0.33 h / 120 °C / Inert atmosphere; Microwave irradiation

With potassium acetate; sodium carbonate; caesium carbonate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In 1,2-dimethoxyethane; ethanol; dimethyl sulfoxide; N,N-dimethyl-formamide;

Reference yield:

ethyl {1-[5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyrimidin-2-yl]piperidin-4-yl}acetate (1388144-31-7) + 4-bromo-2-fluorobenzaldehyde (57848-46-1) → ethyl {1-[5-(3-fluoro-4-formylphenyl)pyrimidin-2-yl]piperidin-4-yl}acetate (1388144-32-8)

Guidance literature:

With sodium carbonate; In 1,2-dimethoxyethane; ethanol; at 120 ℃; for 0.333333h; Inert atmosphere; Microwave irradiation;

Reference yield:

ethyl [1-(5-bromopyrimidin-2-yl)piperidin-4-yl]acetate (1388144-29-3) → ethyl {1-[5-(3-fluoro-4-formylphenyl)pyrimidin-2-yl]piperidin-4-yl}acetate (1388144-32-8)

Guidance literature:

Multi-step reaction with 2 steps

1: potassium acetate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / dimethyl sulfoxide / 18 h / 100 °C / Inert atmosphere

2: sodium carbonate / 1,2-dimethoxyethane; ethanol / 0.33 h / 120 °C / Inert atmosphere; Microwave irradiation

With potassium acetate; sodium carbonate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In 1,2-dimethoxyethane; ethanol; dimethyl sulfoxide;

upstream raw materials:

ethyl {1-[5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyrimidin-2-yl]piperidin-4-yl}acetate

4-bromo-2-fluorobenzaldehyde

ethyl (piperidin-4-yl)acetate

ethyl [1-(5-bromopyrimidin-2-yl)piperidin-4-yl]acetate