5-Ethyl-4-(1-hydroxy-3,5-dimethylcyclohexylmethyl)-2,6-dimethoxynicotinonitrile

Base Information

Chemical Name:5-Ethyl-4-(1-hydroxy-3,5-dimethylcyclohexylmethyl)-2,6-dimethoxynicotinonitrile
CAS No.:389057-61-8
Molecular Formula:C₁₉H₂₈N₂O₃
Molecular Weight:332.443
Hs Code.:

Synonyms:5-Ethyl-4-(1-hydroxy-3,5-dimethylcyclohexylmethyl)-2,6-dimethoxynicotinonitrile

Suppliers and Price of 5-Ethyl-4-(1-hydroxy-3,5-dimethylcyclohexylmethyl)-2,6-dimethoxynicotinonitrile

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 5-Ethyl-4-(1-hydroxy-3,5-dimethylcyclohexylmethyl)-2,6-dimethoxynicotinonitrile

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 5-Ethyl-4-(1-hydroxy-3,5-dimethylcyclohexylmethyl)-2,6-dimethoxynicotinonitrile

There total 1 articles about 5-Ethyl-4-(1-hydroxy-3,5-dimethylcyclohexylmethyl)-2,6-dimethoxynicotinonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 52.0%

: 2320-30-1
3,5-dimethylcyclohexanone

: 252950-80-4
3-cyano-2,6-dimethoxy-5-ethyl-4-methylpyridine

: Spiro{3,5-dimethylcyclohexane-1,3'-[5'-ethyl-6',8'-dimethoxy-3',4'-dihydropyrano[3',4'-c]pyridin-1'-one]}

: 389057-61-8
5-Ethyl-4-(1-hydroxy-3,5-dimethylcyclohexylmethyl)-2,6-dimethoxynicotinonitrile

Guidance literature:: 3-cyano-2,6-dimethoxy-5-ethyl-4-methylpyridine; With lithium diisopropyl amide; In tetrahydrofuran; at -78 ℃; for 0.5h;

3,5-dimethylcyclohexanone; In tetrahydrofuran; at -78 - 25 ℃;
DOI:10.1055/s-2001-17526

Reference yield: 65.0%

: 389057-61-8
5-Ethyl-4-(1-hydroxy-3,5-dimethylcyclohexylmethyl)-2,6-dimethoxynicotinonitrile

: 389057-59-4
4-(3,5-Dimethylbenzyl)-5-ethyl-2,6-dimethoxynicotinonitrile

: 4-(3,5-Dimethylcyclohexylmethyl)-5-ethyl-2,6-dimethoxynicotinonitrile

Guidance literature:: 5-Ethyl-4-(1-hydroxy-3,5-dimethylcyclohexylmethyl)-2,6-dimethoxynicotinonitrile; With pyridine; trichlorophosphate; for 0.666667h; Heating;

10% palladium on active carbon; In various solvent(s); at 190 ℃;
DOI:10.1055/s-2001-17526

Reference yield:

: 389057-61-8
5-Ethyl-4-(1-hydroxy-3,5-dimethylcyclohexylmethyl)-2,6-dimethoxynicotinonitrile

: 3-Cyano-4-(3,5-dimethylbenzyl)-5-ethyl-6-hydroxypyridin-2(1H)-one

Guidance literature:: Multi-step reaction with 2 steps

1.1: pyridine; POCl₃ / 0.67 h / Heating

1.2: 65 percent / 10 percentPd/C / various solvent(s) / 190 °C

2.1: 30 percent / t-BuOK; crown ether 18-C-6 / ethane-1,2-diol / 0.17 h / 200 °C / microwave irradiation

With pyridine; 18-crown-6 ether; potassium tert-butylate; trichlorophosphate; In ethylene glycol;
DOI:10.1055/s-2001-17526