(S)-1-(1-(5-chloropyrazin-2-yl)piperidin-4-yl)-3-(2-fluoro-4-(5-methyl-1,3,4-oxadiazol-2-yl)phenoxy)pyrrolidin-2-one

Base Information

Chemical Name:(S)-1-(1-(5-chloropyrazin-2-yl)piperidin-4-yl)-3-(2-fluoro-4-(5-methyl-1,3,4-oxadiazol-2-yl)phenoxy)pyrrolidin-2-one
CAS No.:1351166-82-9
Molecular Formula:C₂₂H₂₂ClFN₆O₃
Molecular Weight:472.906
Hs Code.:

Synonyms:(S)-1-(1-(5-chloropyrazin-2-yl)piperidin-4-yl)-3-(2-fluoro-4-(5-methyl-1,3,4-oxadiazol-2-yl)phenoxy)pyrrolidin-2-one

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Chemical Property of (S)-1-(1-(5-chloropyrazin-2-yl)piperidin-4-yl)-3-(2-fluoro-4-(5-methyl-1,3,4-oxadiazol-2-yl)phenoxy)pyrrolidin-2-one

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Technology Process of (S)-1-(1-(5-chloropyrazin-2-yl)piperidin-4-yl)-3-(2-fluoro-4-(5-methyl-1,3,4-oxadiazol-2-yl)phenoxy)pyrrolidin-2-one

There total 8 articles about (S)-1-(1-(5-chloropyrazin-2-yl)piperidin-4-yl)-3-(2-fluoro-4-(5-methyl-1,3,4-oxadiazol-2-yl)phenoxy)pyrrolidin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 19745-07-4
2,5-dichloropyrazine

: 1351168-90-5
(S)-3-(2-fluoro-4-(5-methyl-1,3,4-oxadiazol-2-yl)phenoxy)-1-(piperidin-4-yl)pyrrolidin-2-one 2,2,2-trifluoroacetate

: 1351166-82-9
(S)-1-(1-(5-chloropyrazin-2-yl)piperidin-4-yl)-3-(2-fluoro-4-(5-methyl-1,3,4-oxadiazol-2-yl)phenoxy)pyrrolidin-2-one

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In dimethyl sulfoxide; at 100 ℃;

Reference yield:

: 87120-72-7
1-(tert-butoxycarbonyl)-4-aminopiperidine

: 1351166-82-9
(S)-1-(1-(5-chloropyrazin-2-yl)piperidin-4-yl)-3-(2-fluoro-4-(5-methyl-1,3,4-oxadiazol-2-yl)phenoxy)pyrrolidin-2-one

Guidance literature:: Multi-step reaction with 8 steps

1.1: acetic acid / 1,2-dichloro-ethane / 0.25 h / 20 °C

1.2: 20 °C

2.1: triethylamine / tetrahydrofuran / 1 h / 20 °C

3.1: potassium carbonate / N,N-dimethyl-formamide / 60 °C

4.1: potassium trimethylsilonate / tetrahydrofuran / 5 h / 20 °C

5.1: bis-(2-oxo-3-oxazolidinyl)phosphoryl chloride; N-ethyl-N,N-diisopropylamine / dichloromethane / 3 h / 20 °C

6.1: carbon tetrabromide; 1H-imidazole; triphenylphosphine / dichloromethane / 0 - 20 °C / Inert atmosphere

7.1: dichloromethane / 1 h / 20 °C

8.1: N-ethyl-N,N-diisopropylamine / dimethyl sulfoxide / 100 °C

With 1H-imidazole; carbon tetrabromide; potassium trimethylsilonate; bis-(2-oxo-3-oxazolidinyl)phosphoryl chloride; potassium carbonate; acetic acid; triethylamine; N-ethyl-N,N-diisopropylamine; triphenylphosphine; In tetrahydrofuran; dichloromethane; dimethyl sulfoxide; 1,2-dichloro-ethane; N,N-dimethyl-formamide;

Reference yield:

: 1351168-46-1
(S)-tert-butyl 4-(3-(4-(2-acetylhydrazinecarbonyl)-2-fluorophenoxy)-2-oxopyrrolidin-1-yl)piperidin-1-carboxylate

: 1351166-82-9
(S)-1-(1-(5-chloropyrazin-2-yl)piperidin-4-yl)-3-(2-fluoro-4-(5-methyl-1,3,4-oxadiazol-2-yl)phenoxy)pyrrolidin-2-one

Guidance literature:: Multi-step reaction with 3 steps

1: carbon tetrabromide; 1H-imidazole; triphenylphosphine / dichloromethane / 0 - 20 °C / Inert atmosphere

2: dichloromethane / 1 h / 20 °C

3: N-ethyl-N,N-diisopropylamine / dimethyl sulfoxide / 100 °C

With 1H-imidazole; carbon tetrabromide; N-ethyl-N,N-diisopropylamine; triphenylphosphine; In dichloromethane; dimethyl sulfoxide;