Mosher amide of trans-4-carboxy-D-proline dimethyl ester

Base Information

• Chemical Name: Mosher amide of trans-4-carboxy-D-proline dimethyl ester
• CAS No.: 130830-82-9
• Molecular Formula: C₁₈H₂₀F₃NO₆
• Molecular Weight: 403.355
• Mol file: 130830-82-9.mol

Synonyms:Mosher amide of trans-4-carboxy-D-proline dimethyl ester

Chemical Property of Mosher amide of trans-4-carboxy-D-proline dimethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Mosher amide of trans-4-carboxy-D-proline dimethyl ester

There total 7 articles about Mosher amide of trans-4-carboxy-D-proline dimethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

N-(benzyloxycarbonyl)-trans-4-cyano-D-proline ethyl ester (130830-67-0) → Mosher amide of trans-4-carboxy-D-proline dimethyl ester (130830-82-9)

Guidance literature:

Multi-step reaction with 3 steps

1: 94 percent / HCl / 96 h

2: H₂ / 10percent Pd/C / ethanol / 0.5 h / 2585.7 Torr

3: 16 h / Ambient temperature

With hydrogenchloride; hydrogen; palladium on activated charcoal; In ethanol;

DOI:10.1021/jm00106a037

Reference yield:

(2R,4R)-2-ethoxycarbonyl-4-hydroxy-N-(benzyloxycarbonyl)pyrrolidine (130930-27-7) → Mosher amide of trans-4-carboxy-D-proline dimethyl ester (130830-82-9)

Guidance literature:

Multi-step reaction with 5 steps

1: 92 percent / pyridine / CHCl₃ / 168 h / Ambient temperature

2: 72 percent / dimethylsulfoxide / 4 h / 80 °C

3: 94 percent / HCl / 96 h

4: H₂ / 10percent Pd/C / ethanol / 0.5 h / 2585.7 Torr

5: 16 h / Ambient temperature

With pyridine; hydrogenchloride; hydrogen; palladium on activated charcoal; In ethanol; chloroform; dimethyl sulfoxide;

DOI:10.1021/jm00106a037

Reference yield:

N-(benzyloxycarbonyl)-trans-4-carboxy-D-proline dimethyl ester (130830-71-6) → Mosher amide of trans-4-carboxy-D-proline dimethyl ester (130830-82-9)

Guidance literature:

Multi-step reaction with 2 steps

1: H₂ / 10percent Pd/C / ethanol / 0.5 h / 2585.7 Torr

2: 16 h / Ambient temperature

With hydrogen; palladium on activated charcoal; In ethanol;

DOI:10.1021/jm00106a037

upstream raw materials:

(S)-(+)-2-methoxy-2-trifluoromethyl-2-phenylacetyl chloride

trans-4-carboxy-D-proline dimethyl ester

(2R,4R)-2-ethoxycarbonyl-4-hydroxy-N-(benzyloxycarbonyl)pyrrolidine

N-(benzyloxycarbonyl)-trans-4-cyano-D-proline ethyl ester