(2,4-dichlorophenyl)[2-nitro-4-(E-((3-(2-oxopyrrolidin-1-yl)propylamino)carbonyl)ethenyl)phenyl]sulfide

Base Information

• Chemical Name: (2,4-dichlorophenyl)[2-nitro-4-(E-((3-(2-oxopyrrolidin-1-yl)propylamino)carbonyl)ethenyl)phenyl]sulfide
• CAS No.: 280749-00-0
• Molecular Formula: C₂₂H₂₁Cl₂N₃O₄S
• Molecular Weight: 494.398

Synonyms:(2,4-dichlorophenyl)[2-nitro-4-(E-((3-(2-oxopyrrolidin-1-yl)propylamino)carbonyl)ethenyl)phenyl]sulfide

Chemical Property of (2,4-dichlorophenyl)[2-nitro-4-(E-((3-(2-oxopyrrolidin-1-yl)propylamino)carbonyl)ethenyl)phenyl]sulfide

Chemical Property:

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Technology Process of (2,4-dichlorophenyl)[2-nitro-4-(E-((3-(2-oxopyrrolidin-1-yl)propylamino)carbonyl)ethenyl)phenyl]sulfide

There total 4 articles about (2,4-dichlorophenyl)[2-nitro-4-(E-((3-(2-oxopyrrolidin-1-yl)propylamino)carbonyl)ethenyl)phenyl]sulfide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2,4-dichlorobenzenethiol (1122-41-4) + 3-(4-chloro-3-nitro-phenyl)-N-[3-(2-oxo-pyrrolidin-1-yl)-propyl]-acrylamide (280752-92-3) → (2,4-dichlorophenyl)[2-nitro-4-(E-((3-(2-oxopyrrolidin-1-yl)propylamino)carbonyl)ethenyl)phenyl]sulfide (280749-00-0)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; at 20 ℃; for 1h;

DOI:10.1021/jm0002782

Reference yield:

1-(3-aminopropyl)-2-pyrrolidone (7663-77-6) → (2,4-dichlorophenyl)[2-nitro-4-(E-((3-(2-oxopyrrolidin-1-yl)propylamino)carbonyl)ethenyl)phenyl]sulfide (280749-00-0)

Guidance literature:

Multi-step reaction with 2 steps

1: EDAC / dimethylformamide / 2 h / 20 °C

2: K₂CO₃ / dimethylformamide / 1 h / 20 °C

With potassium carbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In N,N-dimethyl-formamide; 1: Acylation / 2: Substitution;

DOI:10.1021/jm0002782

Reference yield:

(E)-4-chloro-3-nitrocinnamic acid (20797-48-2,199679-38-4) → (2,4-dichlorophenyl)[2-nitro-4-(E-((3-(2-oxopyrrolidin-1-yl)propylamino)carbonyl)ethenyl)phenyl]sulfide (280749-00-0)

Guidance literature:

Multi-step reaction with 2 steps

1: EDAC / dimethylformamide / 2 h / 20 °C

2: K₂CO₃ / dimethylformamide / 1 h / 20 °C

With potassium carbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In N,N-dimethyl-formamide; 1: Acylation / 2: Substitution;

DOI:10.1021/jm0002782

upstream raw materials:

2,4-dichlorobenzenethiol

3-(4-chloro-3-nitro-phenyl)-N-[3-(2-oxo-pyrrolidin-1-yl)-propyl]-acrylamide

1-(3-aminopropyl)-2-pyrrolidone

(E)-4-chloro-3-nitrocinnamic acid

Downstream raw materials:

(2,4-dichlorophenyl)[2-bromo-4-(E-((3-(2-oxopyrrolidin-1-yl)propylamino)carbonyl)ethenyl)phenyl]sulfide

(2,4-dichlorophenyl)[2-amino-4-(E-((3-(2-oxopyrrolidin-1-yl)propylamino)carbonyl)ethenyl)phenyl]sulfide

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