N-[N^2',N^6'-bis(2,3-diacetoxybenzoyl)-L-lysyl]-L-glutamic acid 5-(N-benzyloxy-N-methyl)amide

Base Information

• Chemical Name: N-[N^2',N^6'-bis(2,3-diacetoxybenzoyl)-L-lysyl]-L-glutamic acid 5-(N-benzyloxy-N-methyl)amide
• CAS No.: 439152-24-6
• Molecular Formula: C₄₁H₄₄N₄O₁₆
• Molecular Weight: 848.818

Synonyms:N-[N^2',N^6'-bis(2,3-diacetoxybenzoyl)-L-lysyl]-L-glutamic acid 5-(N-benzyloxy-N-methyl)amide

Chemical Property of N-[N^2',N^6'-bis(2,3-diacetoxybenzoyl)-L-lysyl]-L-glutamic acid 5-(N-benzyloxy-N-methyl)amide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-[N^2',N^6'-bis(2,3-diacetoxybenzoyl)-L-lysyl]-L-glutamic acid 5-(N-benzyloxy-N-methyl)amide

There total 5 articles about N-[N^2',N^6'-bis(2,3-diacetoxybenzoyl)-L-lysyl]-L-glutamic acid 5-(N-benzyloxy-N-methyl)amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(S)-4-(Benzoyloxy-methyl-carbamoyl)-2-[(S)-2,6-bis-(2,3-diacetoxy-benzoylamino)-hexanoylamino]-butyric acid benzyl ester (452303-69-4) → N-[N2',N6'-bis(2,3-diacetoxybenzoyl)-L-lysyl]-L-glutamic acid 5-(N-benzyloxy-N-methyl)amide (439152-24-6)

Guidance literature:

With hydrogen; palladium on activated charcoal; at 20 ℃; atmospheric pressure;

DOI:10.1016/S0968-0896(02)00044-5

Reference yield:

L-lysine (56-87-1,3506-25-0) → N-[N2',N6'-bis(2,3-diacetoxybenzoyl)-L-lysyl]-L-glutamic acid 5-(N-benzyloxy-N-methyl)amide (439152-24-6)

Guidance literature:

Multi-step reaction with 4 steps

1.1: 45 percent / aq. NaHCO₃ / tetrahydrofuran / 1 h / 0 - 5 °C

2.1: i-BuOCOCl; N-methylmorpholine / tetrahydrofuran / 0.75 h / -10 °C

2.2: 30 percent / Et₃N / tetrahydrofuran / 2 h / -10 - 20 °C

3.1: i-BuOCOCl; N-methylmorpholine / tetrahydrofuran / 0.75 h / -10 °C

3.2: 40 percent / Et₃N / tetrahydrofuran / 2 h / -10 - 20 °C

4.1: H₂ / 10 percent Pd/C / 20 °C / atmospheric pressure

With 4-methyl-morpholine; hydrogen; sodium hydrogencarbonate; isobutyl chloroformate; palladium on activated charcoal; In tetrahydrofuran;

DOI:10.1016/S0968-0896(02)00044-5

Reference yield:

2,3-bis(acetyloxy)benzoyl chloride (65055-19-8) → N-[N2',N6'-bis(2,3-diacetoxybenzoyl)-L-lysyl]-L-glutamic acid 5-(N-benzyloxy-N-methyl)amide (439152-24-6)

Guidance literature:

Multi-step reaction with 4 steps

1.1: 45 percent / aq. NaHCO₃ / tetrahydrofuran / 1 h / 0 - 5 °C

2.1: i-BuOCOCl; N-methylmorpholine / tetrahydrofuran / 0.75 h / -10 °C

2.2: 30 percent / Et₃N / tetrahydrofuran / 2 h / -10 - 20 °C

3.1: i-BuOCOCl; N-methylmorpholine / tetrahydrofuran / 0.75 h / -10 °C

3.2: 40 percent / Et₃N / tetrahydrofuran / 2 h / -10 - 20 °C

4.1: H₂ / 10 percent Pd/C / 20 °C / atmospheric pressure

With 4-methyl-morpholine; hydrogen; sodium hydrogencarbonate; isobutyl chloroformate; palladium on activated charcoal; In tetrahydrofuran;

DOI:10.1016/S0968-0896(02)00044-5

upstream raw materials:

(S)-4-(Benzoyloxy-methyl-carbamoyl)-2-[(S)-2,6-bis-(2,3-diacetoxy-benzoylamino)-hexanoylamino]-butyric acid benzyl ester

L-lysine

2,3-bis(acetyloxy)benzoyl chloride

N²,N⁶-bis(2,3-diacetoxybenzoyl)-L-lysine

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 439152-24-6 N-[N^2',N^6'-bis(2,3-diacetoxybenzoyl)-L-lysyl]-L-glutamic acid 5-(N-benzyloxy-N-methyl)amide

Send

Send

Metric Ton KG G Pound L ML

Send

Send