pyrrolidine-1-carboxylic acid [3-(5-cyclopropyl-4-{3-[(thiophene-2-carbonyl)-amino]-propylamino}-pyrimidin-2-ylamino)-phenyl]-amide

Base Information

Chemical Name:pyrrolidine-1-carboxylic acid [3-(5-cyclopropyl-4-{3-[(thiophene-2-carbonyl)-amino]-propylamino}-pyrimidin-2-ylamino)-phenyl]-amide
CAS No.:1190377-89-9
Molecular Formula:C₂₆H₃₁N₇O₂S
Molecular Weight:505.644
Hs Code.:

Synonyms:pyrrolidine-1-carboxylic acid [3-(5-cyclopropyl-4-{3-[(thiophene-2-carbonyl)-amino]-propylamino}-pyrimidin-2-ylamino)-phenyl]-amide

Suppliers and Price of pyrrolidine-1-carboxylic acid [3-(5-cyclopropyl-4-{3-[(thiophene-2-carbonyl)-amino]-propylamino}-pyrimidin-2-ylamino)-phenyl]-amide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of pyrrolidine-1-carboxylic acid [3-(5-cyclopropyl-4-{3-[(thiophene-2-carbonyl)-amino]-propylamino}-pyrimidin-2-ylamino)-phenyl]-amide

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of pyrrolidine-1-carboxylic acid [3-(5-cyclopropyl-4-{3-[(thiophene-2-carbonyl)-amino]-propylamino}-pyrimidin-2-ylamino)-phenyl]-amide

There total 8 articles about pyrrolidine-1-carboxylic acid [3-(5-cyclopropyl-4-{3-[(thiophene-2-carbonyl)-amino]-propylamino}-pyrimidin-2-ylamino)-phenyl]-amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 12.0%

: 702638-74-2
pyrrolidine-1-carboxylic acid (3-amino-phenyl)-amide

: 1190379-92-0
thiophene-2-carboxylic acid [3-(2-chloro-5-cyclopropyl-pyrimidin-4-ylamino)-propyl]-amide

: 1190377-89-9
pyrrolidine-1-carboxylic acid [3-(5-cyclopropyl-4-{3-[(thiophene-2-carbonyl)-amino]-propylamino}-pyrimidin-2-ylamino)-phenyl]-amide

Guidance literature:: With sodium t-butanolate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In 1,4-dioxane; at 105 ℃; for 18h; Inert atmosphere;

Reference yield:

: 5271-67-0
2-Thiophenecarbonyl chloride

: 1190377-89-9
pyrrolidine-1-carboxylic acid [3-(5-cyclopropyl-4-{3-[(thiophene-2-carbonyl)-amino]-propylamino}-pyrimidin-2-ylamino)-phenyl]-amide

Guidance literature:: Multi-step reaction with 2 steps

1: triethylamine / dichloromethane / 20 °C

2: sodium t-butanolate / tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene / 1,4-dioxane / 18 h / 105 °C / Inert atmosphere

With triethylamine; sodium t-butanolate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In 1,4-dioxane; dichloromethane;

Reference yield:

: 35799-28-1
N-(3-nitrophenyl)pyrrolidine-1-carboxamide

: 1190377-89-9
pyrrolidine-1-carboxylic acid [3-(5-cyclopropyl-4-{3-[(thiophene-2-carbonyl)-amino]-propylamino}-pyrimidin-2-ylamino)-phenyl]-amide

Guidance literature:: Multi-step reaction with 2 steps

1: hydrogen / palladium 10% on activated carbon / ethanol; ethyl acetate / 22 h / 20 °C

2: sodium t-butanolate / tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene / 1,4-dioxane / 18 h / 105 °C / Inert atmosphere

With hydrogen; sodium t-butanolate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; palladium 10% on activated carbon; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In 1,4-dioxane; ethanol; ethyl acetate;