Technology Process of 1,4-bis(9-benzyl-β-carboline-3-carboxylic acid)butanediyl ester
There total 5 articles about 1,4-bis(9-benzyl-β-carboline-3-carboxylic acid)butanediyl ester which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
potassium carbonate;
In
N,N-dimethyl-formamide;
at 80 ℃;
for 6 - 10h;
DOI:10.1039/c4md00098f
- Guidance literature:
-
With
potassium carbonate;
In
N,N-dimethyl-formamide;
for 14h;
Heating;
- Guidance literature:
-
Multi-step reaction with 6 steps
1: 20 °C / Acidic conditions
2: sulfuryl dichloride / Reflux
3: palladium on activated charcoal / 5,5-dimethyl-1,3-cyclohexadiene / Reflux
4: sodium hydride / N,N-dimethyl-formamide / 20 °C
5: tetrahydrofuran; methanol / 20 °C / Alkaline conditions
6: potassium carbonate / N,N-dimethyl-formamide / Heating
With
sulfuryl dichloride; palladium on activated charcoal; sodium hydride; potassium carbonate;
In
tetrahydrofuran; methanol; 5,5-dimethyl-1,3-cyclohexadiene; N,N-dimethyl-formamide;
1: |Pictet-Spengler Synthesis;
DOI:10.3390/ijms19103179
