Technology Process of 3-[(E)-2-(4-chlorophenyl)vinyl]-4-ethoxybenzoic acid
There total 4 articles about 3-[(E)-2-(4-chlorophenyl)vinyl]-4-ethoxybenzoic acid which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
ethyl 3-[(E)-2-(4-chlorophenyl)vinyl]-4-ethoxybenzoate;
With
potassium hydroxide;
In
methanol; water;
for 1h;
Reflux;
With
hydrogenchloride;
In
water;
DOI:10.1016/j.bmc.2011.12.058
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: triethylamine; magnesium chloride / 1,2-dichloro-ethane / 1 h / 40 °C
1.2: 3 h / 70 °C
2.1: sodium tert-pentoxide / N,N-dimethyl-formamide / 0.33 h / 0 °C
2.2: 2 h / 0 °C
3.1: potassium carbonate / acetonitrile / 24 h / 60 °C
4.1: potassium hydroxide / methanol; water / 1 h / Reflux
With
sodium tert-pentoxide; potassium carbonate; triethylamine; potassium hydroxide; magnesium chloride;
In
methanol; water; 1,2-dichloro-ethane; N,N-dimethyl-formamide; acetonitrile;
2.2: Horner-Wadsworth-Emmons olefination;
DOI:10.1016/j.bmc.2011.12.058
- Guidance literature:
-
Multi-step reaction with 2 steps
1: potassium carbonate / acetonitrile / 24 h / 60 °C
2: potassium hydroxide / methanol; water / 1 h / Reflux
With
potassium carbonate; potassium hydroxide;
In
methanol; water; acetonitrile;
DOI:10.1016/j.bmc.2011.12.058
![ethyl 3-[(E)-2-(4-chlorophenyl)vinyl]-4-ethoxybenzoate](/Databaselist/images/loading.webp)
