4-(4-chloro-2-fluoro-phenylamino)-5,7-dihydro-pyrrolo[2,3-d]pyrimidin-6-one

Base Information

• Chemical Name: 4-(4-chloro-2-fluoro-phenylamino)-5,7-dihydro-pyrrolo[2,3-d]pyrimidin-6-one
• CAS No.: 865364-29-0
• Molecular Formula: C₁₂H₈ClFN₄O
• Molecular Weight: 278.673

Synonyms:4-(4-chloro-2-fluoro-phenylamino)-5,7-dihydro-pyrrolo[2,3-d]pyrimidin-6-one

Chemical Property of 4-(4-chloro-2-fluoro-phenylamino)-5,7-dihydro-pyrrolo[2,3-d]pyrimidin-6-one

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Technology Process of 4-(4-chloro-2-fluoro-phenylamino)-5,7-dihydro-pyrrolo[2,3-d]pyrimidin-6-one

There total 3 articles about 4-(4-chloro-2-fluoro-phenylamino)-5,7-dihydro-pyrrolo[2,3-d]pyrimidin-6-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

(4-chloro-2-fluoro-phenyl)-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-amine (865364-20-1) → 4-(4-chloro-2-fluoro-phenylamino)-5,7-dihydro-pyrrolo[2,3-d]pyrimidin-6-one (865364-29-0)

Guidance literature:

(4-chloro-2-fluoro-phenyl)-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-amine; With pyridinium hydrobromide perbromide; acetic acid; In tert-butyl alcohol;

With zinc;

DOI:10.1016/S0960-894X(02)00364-5

Reference yield:

7-deazahypoxanthine (3680-71-5) → 4-(4-chloro-2-fluoro-phenylamino)-5,7-dihydro-pyrrolo[2,3-d]pyrimidin-6-one (865364-29-0)

Guidance literature:

Multi-step reaction with 3 steps

1.1: 92 percent / POCl₃

2.1: 98 percent / AgOTf / dimethylformamide / 90 °C

3.1: pyridinium bromide perbromide; AcOH / 2-methyl-propan-2-ol

3.2: 77 percent / Zn

With silver trifluoromethanesulfonate; pyridinium hydrobromide perbromide; acetic acid; trichlorophosphate; In N,N-dimethyl-formamide; tert-butyl alcohol;

DOI:10.1016/S0960-894X(02)00364-5

Reference yield:

4-chloro-1H-pyrrolo[2,3-d]pyrimidine (3680-69-1) → 4-(4-chloro-2-fluoro-phenylamino)-5,7-dihydro-pyrrolo[2,3-d]pyrimidin-6-one (865364-29-0)

Guidance literature:

Multi-step reaction with 2 steps

1.1: 98 percent / AgOTf / dimethylformamide / 90 °C

2.1: pyridinium bromide perbromide; AcOH / 2-methyl-propan-2-ol

2.2: 77 percent / Zn

With silver trifluoromethanesulfonate; pyridinium hydrobromide perbromide; acetic acid; In N,N-dimethyl-formamide; tert-butyl alcohol;

DOI:10.1016/S0960-894X(02)00364-5

upstream raw materials:

(4-chloro-2-fluoro-phenyl)-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-amine

7-deazahypoxanthine

4-chloro-1H-pyrrolo[2,3-d]pyrimidine

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