4-{[3-(trifluoromethoxy)phenyl]amino}-5,6,7,8-tetrahydro-5,8-methanoisoquinolin-1-yl trifluoromethanesulfonate

Base Information

Chemical Name:4-{[3-(trifluoromethoxy)phenyl]amino}-5,6,7,8-tetrahydro-5,8-methanoisoquinolin-1-yl trifluoromethanesulfonate
CAS No.:1357185-88-6
Molecular Formula:C₁₈H₁₄F₆N₂O₄S
Molecular Weight:468.377
Hs Code.:

Synonyms:4-{[3-(trifluoromethoxy)phenyl]amino}-5,6,7,8-tetrahydro-5,8-methanoisoquinolin-1-yl trifluoromethanesulfonate

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Chemical Property of 4-{[3-(trifluoromethoxy)phenyl]amino}-5,6,7,8-tetrahydro-5,8-methanoisoquinolin-1-yl trifluoromethanesulfonate

Chemical Property:

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Technology Process of 4-{[3-(trifluoromethoxy)phenyl]amino}-5,6,7,8-tetrahydro-5,8-methanoisoquinolin-1-yl trifluoromethanesulfonate

There total 6 articles about 4-{[3-(trifluoromethoxy)phenyl]amino}-5,6,7,8-tetrahydro-5,8-methanoisoquinolin-1-yl trifluoromethanesulfonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 358-23-6
trifluoromethylsulfonic anhydride

: 1357185-87-5
4-{[3-(trifluoromethoxy)phenyl]amino}-5,6,7,8-tetrahydro-5,8-methanoisoquinolin-1(2H)-one

: 1357185-88-6
4-{[3-(trifluoromethoxy)phenyl]amino}-5,6,7,8-tetrahydro-5,8-methanoisoquinolin-1-yl trifluoromethanesulfonate

Guidance literature:: With pyridine; In dichloromethane; for 1h; Cooling with ice;

Reference yield:

: 1357185-86-4
1-methoxy-N-[3-(trifluoromethoxy)phenyl]-5,6,7,8-tetrahydro-5,8-methanoisoquinoline-4-amine

: 1357185-88-6
4-{[3-(trifluoromethoxy)phenyl]amino}-5,6,7,8-tetrahydro-5,8-methanoisoquinolin-1-yl trifluoromethanesulfonate

Guidance literature:: Multi-step reaction with 2 steps

1: chloro-trimethyl-silane; sodium iodide / acetonitrile / 60 °C

2: pyridine / dichloromethane / 1 h / Cooling with ice

With pyridine; chloro-trimethyl-silane; sodium iodide; In dichloromethane; acetonitrile;

Reference yield:

: 145041-54-9
1-(methylsulfanyl)-5,6,7,8-tetrahydro-5,8-methanoisoquinoline

: 1357185-88-6
4-{[3-(trifluoromethoxy)phenyl]amino}-5,6,7,8-tetrahydro-5,8-methanoisoquinolin-1-yl trifluoromethanesulfonate

Guidance literature:: Multi-step reaction with 6 steps

1: 3-chloro-benzenecarboperoxoic acid / chloroform / 2 h / 20 °C / Cooling with ice

2: sodium methylate / methanol / 15 h / Reflux

3: N-Bromosuccinimide / chloroform / 36 h / 20 °C

4: 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; sodium t-butanolate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / toluene / 16 h / 100 °C / Inert atmosphere

5: chloro-trimethyl-silane; sodium iodide / acetonitrile / 60 °C

6: pyridine / dichloromethane / 1 h / Cooling with ice

With pyridine; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; N-Bromosuccinimide; chloro-trimethyl-silane; sodium methylate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; 3-chloro-benzenecarboperoxoic acid; sodium iodide; sodium t-butanolate; In methanol; dichloromethane; chloroform; toluene; acetonitrile;