(1S,2R,6R)-2-Hydroxy-4-oxo-2,6-diphenyl-cyclohexanecarboxylic acid benzyl ester

Base Information

• Chemical Name: (1S,2R,6R)-2-Hydroxy-4-oxo-2,6-diphenyl-cyclohexanecarboxylic acid benzyl ester
• CAS No.: 688800-78-4
• Molecular Formula: C₂₆H₂₄O₄
• Molecular Weight: 400.474

Synonyms:(1S,2R,6R)-2-Hydroxy-4-oxo-2,6-diphenyl-cyclohexanecarboxylic acid benzyl ester

Chemical Property of (1S,2R,6R)-2-Hydroxy-4-oxo-2,6-diphenyl-cyclohexanecarboxylic acid benzyl ester

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Technology Process of (1S,2R,6R)-2-Hydroxy-4-oxo-2,6-diphenyl-cyclohexanecarboxylic acid benzyl ester

There total 3 articles about (1S,2R,6R)-2-Hydroxy-4-oxo-2,6-diphenyl-cyclohexanecarboxylic acid benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

benzyl benzoylacetate (63888-22-2) + 1-Phenylbut-1-en-3-one (122-57-6) → (1S,2R,6R)-2-Hydroxy-4-oxo-2,6-diphenyl-cyclohexanecarboxylic acid benzyl ester (688800-78-4)

Guidance literature:

With benzoic acid; (S)-N¹-methyl-3-phenylpropane-1,2-diamine; In ethanol; at 20 ℃; for 96h; optical yield given as %ee; stereoselective reaction;

DOI:10.1039/c1ob05400g

Reference yield:

benzyl benzoylacetate (63888-22-2) + 1-Phenylbut-1-en-3-one (122-57-6) → (1R,2S,6S)-2-Hydroxy-4-oxo-2,6-diphenyl-cyclohexanecarboxylic acid benzyl ester + (1S,2R,6R)-2-Hydroxy-4-oxo-2,6-diphenyl-cyclohexanecarboxylic acid benzyl ester (688800-78-4)

Guidance literature:

With Glyoxilic acid; (S)-N¹-methyl-3-phenylpropane-1,2-diamine; In ethanol; at 20 ℃; for 72h; optical yield given as %ee; stereoselective reaction;

DOI:10.1039/c1ob05400g

Reference yield:

benzyl benzoylacetate (63888-22-2) + (E)-benzalacetone (1896-62-4) → 2-hydroxy-4-oxo-2,6-diphenyl-cyclohexanecarboxylic acid benzyl ester + (1R,2S,6S)-2-Hydroxy-4-oxo-2,6-diphenyl-cyclohexanecarboxylic acid benzyl ester + (1S,2R,6R)-2-Hydroxy-4-oxo-2,6-diphenyl-cyclohexanecarboxylic acid benzyl ester (688800-78-4)

Guidance literature:

With 4-(S)-benzyl-1-methylimidazolidine-2-carboxylic acid; In ethanol; at 10 ℃; for 190h; Further Variations:; Solvents; Temperatures; reaction times; Product distribution;

DOI:10.1002/anie.200353364

upstream raw materials:

benzyl benzoylacetate

(E)-benzalacetone

1-Phenylbut-1-en-3-one

Downstream raw materials:

(1S,2R,6R)-2-Hydroxy-4-oxo-2,6-diphenyl-cyclohexanecarboxylic acid methyl ester

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