tert-Butyl-{(1R,2R)-1-ethyl-2-[(2R,4R,5R)-2-(4-methoxy-phenyl)-5-methyl-[1,3]dioxan-4-yl]-propoxy}-dimethyl-silane

Base Information

Chemical Name:tert-Butyl-{(1R,2R)-1-ethyl-2-[(2R,4R,5R)-2-(4-methoxy-phenyl)-5-methyl-[1,3]dioxan-4-yl]-propoxy}-dimethyl-silane
CAS No.:604791-31-3
Molecular Formula:C₂₃H₄₀O₄Si
Molecular Weight:408.654
Hs Code.:

Synonyms:tert-Butyl-{(1R,2R)-1-ethyl-2-[(2R,4R,5R)-2-(4-methoxy-phenyl)-5-methyl-[1,3]dioxan-4-yl]-propoxy}-dimethyl-silane

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Chemical Property of tert-Butyl-{(1R,2R)-1-ethyl-2-[(2R,4R,5R)-2-(4-methoxy-phenyl)-5-methyl-[1,3]dioxan-4-yl]-propoxy}-dimethyl-silane

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Technology Process of tert-Butyl-{(1R,2R)-1-ethyl-2-[(2R,4R,5R)-2-(4-methoxy-phenyl)-5-methyl-[1,3]dioxan-4-yl]-propoxy}-dimethyl-silane

There total 6 articles about tert-Butyl-{(1R,2R)-1-ethyl-2-[(2R,4R,5R)-2-(4-methoxy-phenyl)-5-methyl-[1,3]dioxan-4-yl]-propoxy}-dimethyl-silane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 2186-92-7
p-Anisaldehyde dimethyl acetal

: 604791-30-2
(2R,3R,4R,5R)-5-(tert-Butyl-dimethyl-silanyloxy)-2,4-dimethyl-heptane-1,3-diol

: 604791-31-3
tert-Butyl-{(1R,2R)-1-ethyl-2-[(2R,4R,5R)-2-(4-methoxy-phenyl)-5-methyl-[1,3]dioxan-4-yl]-propoxy}-dimethyl-silane

Guidance literature:: With pyridinium p-toluenesulfonate;
DOI:10.1016/S0040-4039(03)01351-0

Reference yield:

: 145937-05-9
(2S,3R)-3-(tert-butyldimethylsilyloxy)-N-methoxy-N,2-dimethylpentanamide

: 604791-31-3
tert-Butyl-{(1R,2R)-1-ethyl-2-[(2R,4R,5R)-2-(4-methoxy-phenyl)-5-methyl-[1,3]dioxan-4-yl]-propoxy}-dimethyl-silane

Guidance literature:: Multi-step reaction with 5 steps

1.1: DIBALH / CH₂Cl₂ / 0 °C

1.2: 90 percent / CH₂Cl₂ / Heating

2.1: 90 percent / DIBALH / CH₂Cl₂ / -23 °C

3.1: 96 percent / m-CPBA / CH₂Cl₂ / 0 °C

4.1: 90 percent / tetrahydrofuran / 0 °C

5.1: 80 percent / PPTS

With pyridinium p-toluenesulfonate; diisobutylaluminium hydride; 3-chloro-benzenecarboperoxoic acid; In tetrahydrofuran; dichloromethane; 1.2: Wittig homologation;
DOI:10.1016/S0040-4039(03)01351-0

Reference yield:

: 124356-91-8
(4S,2'S,3'R)-3-(2'-methyl-3'-hydroxypentanoyl)-4-benzyl-2-oxazolidinone

: 604791-31-3
tert-Butyl-{(1R,2R)-1-ethyl-2-[(2R,4R,5R)-2-(4-methoxy-phenyl)-5-methyl-[1,3]dioxan-4-yl]-propoxy}-dimethyl-silane

Guidance literature:: Multi-step reaction with 6 steps

1.1: Me₃Al; MeONHMe*HCl / tetrahydrofuran / 0 °C

1.2: 81 percent / imidazole / dimethylformamide / 25 °C

2.1: DIBALH / CH₂Cl₂ / 0 °C

2.2: 90 percent / CH₂Cl₂ / Heating

3.1: 90 percent / DIBALH / CH₂Cl₂ / -23 °C

4.1: 96 percent / m-CPBA / CH₂Cl₂ / 0 °C

5.1: 90 percent / tetrahydrofuran / 0 °C

6.1: 80 percent / PPTS

With trimethylaluminum; N,O-dimethylhydroxylamine*hydrochloride; pyridinium p-toluenesulfonate; diisobutylaluminium hydride; 3-chloro-benzenecarboperoxoic acid; In tetrahydrofuran; dichloromethane; 2.2: Wittig homologation;
DOI:10.1016/S0040-4039(03)01351-0