2-(2-(3-hydroxyprop-1-yn-1-yl)-5-(3,5,7-trihydroxy-4-oxo-4H-chromen-2-yl)phenyl)acetonitrile

Base Information

Chemical Name:2-(2-(3-hydroxyprop-1-yn-1-yl)-5-(3,5,7-trihydroxy-4-oxo-4H-chromen-2-yl)phenyl)acetonitrile
CAS No.:1642558-70-0
Molecular Formula:C₂₀H₁₃NO₆
Molecular Weight:363.326
Hs Code.:

Synonyms:2-(2-(3-hydroxyprop-1-yn-1-yl)-5-(3,5,7-trihydroxy-4-oxo-4H-chromen-2-yl)phenyl)acetonitrile

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 2-(2-(3-hydroxyprop-1-yn-1-yl)-5-(3,5,7-trihydroxy-4-oxo-4H-chromen-2-yl)phenyl)acetonitrile

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of 2-(2-(3-hydroxyprop-1-yn-1-yl)-5-(3,5,7-trihydroxy-4-oxo-4H-chromen-2-yl)phenyl)acetonitrile

There total 6 articles about 2-(2-(3-hydroxyprop-1-yn-1-yl)-5-(3,5,7-trihydroxy-4-oxo-4H-chromen-2-yl)phenyl)acetonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₄₀H₄₇NO₁₁

: 1642558-70-0
2-(2-(3-hydroxyprop-1-yn-1-yl)-5-(3,5,7-trihydroxy-4-oxo-4H-chromen-2-yl)phenyl)acetonitrile

Guidance literature:: C₄₀H₄₇NO₁₁; With tetrabutylammomium bromide; potassium carbonate; In toluene; at 90 ℃; for 3h;

With toluene-4-sulfonic acid; In methanol; at 0 - 20 ℃; for 4h;
DOI:10.5012/bkcs.2014.35.8.2581

Reference yield:

: 13157-89-6
2-(benzyloxy)-1-(2,4-bisbenzyloxy-6-hydroxyphenyl)ethanone

: 1642558-70-0
2-(2-(3-hydroxyprop-1-yn-1-yl)-5-(3,5,7-trihydroxy-4-oxo-4H-chromen-2-yl)phenyl)acetonitrile

Guidance literature:: Multi-step reaction with 4 steps

1.1: palladium on activated charcoal; hydrogen / methanol; tetrahydrofuran / 20 °C

2.1: pyridinium p-toluenesulfonate / dichloromethane / 20 °C

3.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; dmap / dichloromethane

3.2: 4 h / 20 °C

4.1: potassium carbonate; tetrabutylammomium bromide / toluene / 3 h / 90 °C

4.2: 4 h / 0 - 20 °C

With dmap; palladium on activated charcoal; tetrabutylammomium bromide; hydrogen; pyridinium p-toluenesulfonate; potassium carbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In tetrahydrofuran; methanol; dichloromethane; toluene;
DOI:10.5012/bkcs.2014.35.8.2581

Reference yield:

: 1379307-14-8
C₉H₆BrNO₂

: 1642558-70-0
2-(2-(3-hydroxyprop-1-yn-1-yl)-5-(3,5,7-trihydroxy-4-oxo-4H-chromen-2-yl)phenyl)acetonitrile

Guidance literature:: Multi-step reaction with 4 steps

1.1: sulfuric acid / methanol / 65 °C

1.2: 65 °C

2.1: pyridinium p-toluenesulfonate / dichloromethane / 20 °C

2.2: 65 °C

3.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; dmap / dichloromethane

3.2: 4 h / 20 °C

4.1: potassium carbonate; tetrabutylammomium bromide / toluene / 3 h / 90 °C

4.2: 4 h / 0 - 20 °C

With dmap; sulfuric acid; tetrabutylammomium bromide; pyridinium p-toluenesulfonate; potassium carbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In methanol; dichloromethane; toluene; 1.2: |Sonogashira Cross-Coupling;
DOI:10.5012/bkcs.2014.35.8.2581