N¹-cholesteryloxycarbonyl-3-aza-N³-2''-nitrobenzenesulfonyl-6,9,12-trioxa-15-benzyloxy-1-amino-tetradecane

Base Information

• Chemical Name: N¹-cholesteryloxycarbonyl-3-aza-N³-2''-nitrobenzenesulfonyl-6,9,12-trioxa-15-benzyloxy-1-amino-tetradecane
• CAS No.: 851219-17-5
• Molecular Formula: C₅₁H₇₇N₃O₁₀S
• Molecular Weight: 924.252

Synonyms:N¹-cholesteryloxycarbonyl-3-aza-N³-2''-nitrobenzenesulfonyl-6,9,12-trioxa-15-benzyloxy-1-amino-tetradecane

Chemical Property of N¹-cholesteryloxycarbonyl-3-aza-N³-2''-nitrobenzenesulfonyl-6,9,12-trioxa-15-benzyloxy-1-amino-tetradecane

Chemical Property:

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Technology Process of N¹-cholesteryloxycarbonyl-3-aza-N³-2''-nitrobenzenesulfonyl-6,9,12-trioxa-15-benzyloxy-1-amino-tetradecane

There total 3 articles about N¹-cholesteryloxycarbonyl-3-aza-N³-2''-nitrobenzenesulfonyl-6,9,12-trioxa-15-benzyloxy-1-amino-tetradecane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

N1-cholesteryloxycarbonyl-1-amino-2''-nitrobenzenesulfonamidoethane (851219-16-4) + 1-phenyl-2,5,8,11-tetraoxatridecan-13-ol (86259-87-2,1201808-31-2) → N1-cholesteryloxycarbonyl-3-aza-N3-2''-nitrobenzenesulfonyl-6,9,12-trioxa-15-benzyloxy-1-amino-tetradecane (851219-17-5)

Guidance literature:

With 2-(diphenylphosphino)pyridine; di-tert-butyl-diazodicarboxylate; In dichloromethane; at 20 ℃;

DOI:10.1039/b418168a

Reference yield:

Cholesteryl chloroformate (7144-08-3) → N1-cholesteryloxycarbonyl-3-aza-N3-2''-nitrobenzenesulfonyl-6,9,12-trioxa-15-benzyloxy-1-amino-tetradecane (851219-17-5)

Guidance literature:

Multi-step reaction with 3 steps

1: 87 percent / CH₂Cl₂ / 18 h / 20 °C

2: 90 percent / diphenyl-2-pyridylphosphine; di-tert-butyl azodicarboxylate / CH₂Cl₂ / 2 h

3: 71 percent / diphenyl 2-pyridylphosphine; di-tert-butyl azodicarboxylate / CH₂Cl₂ / 20 °C

With 2-(diphenylphosphino)pyridine; di-tert-butyl-diazodicarboxylate; In dichloromethane;

DOI:10.1039/b418168a

Reference yield:

N1-cholesteryloxycarbonyl-1-amino-2-hydroxyethane (136099-11-1) → N1-cholesteryloxycarbonyl-3-aza-N3-2''-nitrobenzenesulfonyl-6,9,12-trioxa-15-benzyloxy-1-amino-tetradecane (851219-17-5)

Guidance literature:

Multi-step reaction with 2 steps

1: 90 percent / diphenyl-2-pyridylphosphine; di-tert-butyl azodicarboxylate / CH₂Cl₂ / 2 h

2: 71 percent / diphenyl 2-pyridylphosphine; di-tert-butyl azodicarboxylate / CH₂Cl₂ / 20 °C

With 2-(diphenylphosphino)pyridine; di-tert-butyl-diazodicarboxylate; In dichloromethane;

DOI:10.1039/b418168a

upstream raw materials:

N¹-cholesteryloxycarbonyl-1-amino-2''-nitrobenzenesulfonamidoethane

1-phenyl-2,5,8,11-tetraoxatridecan-13-ol

Cholesteryl chloroformate

N¹-cholesteryloxycarbonyl-1-amino-2-hydroxyethane

Downstream raw materials:

N¹-cholesteryloxycarbonyl-3-aza-N³-t-butoxycarbonyl-6,9,12-trioxa-1-amino-15-O¹⁵-4''-nitrophenyloxycarbonyltetradecane

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