(S)-2,4-dichlorophenyl ethyl 1-<(2S)-2-(methoxymethyl)pyrrolidinyl>phosphonate

Base Information

Chemical Name:(S)-2,4-dichlorophenyl ethyl 1-<(2S)-2-(methoxymethyl)pyrrolidinyl>phosphonate
CAS No.:129149-65-1
Molecular Formula:C₁₄H₂₀Cl₂NO₄P
Molecular Weight:368.197
Hs Code.:

Synonyms:(S)-2,4-dichlorophenyl ethyl 1-<(2S)-2-(methoxymethyl)pyrrolidinyl>phosphonate

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Chemical Property of (S)-2,4-dichlorophenyl ethyl 1-<(2S)-2-(methoxymethyl)pyrrolidinyl>phosphonate

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Technology Process of (S)-2,4-dichlorophenyl ethyl 1-<(2S)-2-(methoxymethyl)pyrrolidinyl>phosphonate

There total 5 articles about (S)-2,4-dichlorophenyl ethyl 1-<(2S)-2-(methoxymethyl)pyrrolidinyl>phosphonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

: 2388-07-0
lithium ethoxide

: 129149-58-2
bis(2,4-dichlorophenyl) 1-<(2S)-2-(methoxymethyl)pyrrolidinyl>phosphonate

: 129149-65-1
(S)-2,4-dichlorophenyl ethyl 1-<(2S)-2-(methoxymethyl)pyrrolidinyl>phosphonate

Guidance literature:: In tetrahydrofuran; at 0 ℃; for 1h;
DOI:10.1021/ja00175a030

Reference yield:

: 63126-47-6
(2S)-2-(methoxymethyl)-1-pyrrolidine

: 129149-65-1
(S)-2,4-dichlorophenyl ethyl 1-<(2S)-2-(methoxymethyl)pyrrolidinyl>phosphonate

Guidance literature:: Multi-step reaction with 2 steps

1: 65 percent / diisopropylethylamine / CH₂Cl₂ / 1.) 0 deg C, 1 h, 2.) RT, overnight

2: 60 percent / tetrahydrofuran / 1 h / 0 °C

With N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; dichloromethane;
DOI:10.1021/ja00175a030

Reference yield:

: 120-83-2,40477-79-0
2,4-dichlorophenol

: 129149-65-1
(S)-2,4-dichlorophenyl ethyl 1-<(2S)-2-(methoxymethyl)pyrrolidinyl>phosphonate

Guidance literature:: Multi-step reaction with 4 steps

1: 14.20 g / phosphoryl chloride, magnesium / 6 h / Heating

2: 7.53 g / magnesium / 5 h / Heating

3: 65 percent / diisopropylethylamine / CH₂Cl₂ / 1.) 0 deg C, 1 h, 2.) RT, overnight

4: 60 percent / tetrahydrofuran / 1 h / 0 °C

With magnesium; N-ethyl-N,N-diisopropylamine; trichlorophosphate; In tetrahydrofuran; dichloromethane;
DOI:10.1021/ja00175a030