benzyl ((6S,9S,11aS,17S,20aS)-6,9,10-trimethyl-5,8,11,16,20-pentaoxohexadecahydro-1H,5H,16Hdipyrrolo[2,1-c:2',1'-l][1]oxa[4,7,10,13]tetraazacyclohexadecin-17-yl)carbamate

Base Information

Chemical Name:benzyl ((6S,9S,11aS,17S,20aS)-6,9,10-trimethyl-5,8,11,16,20-pentaoxohexadecahydro-1H,5H,16Hdipyrrolo[2,1-c:2',1'-l][1]oxa[4,7,10,13]tetraazacyclohexadecin-17-yl)carbamate
CAS No.:192068-64-7
Molecular Formula:C₂₈H₃₇N₅O₈
Molecular Weight:571.63
Hs Code.:

benzyl ((6S,9S,11aS,17S,20aS)-6,9,10-trimethyl-5,8,11,16,20-pentaoxohexadecahydro-1H,5H,16Hdipyrrolo[2,1-c:2',1'-l][1]oxa[4,7,10,13]tetraazacyclohexadecin-17-yl)carbamate

Synonyms:benzyl ((6S,9S,11aS,17S,20aS)-6,9,10-trimethyl-5,8,11,16,20-pentaoxohexadecahydro-1H,5H,16Hdipyrrolo[2,1-c:2',1'-l][1]oxa[4,7,10,13]tetraazacyclohexadecin-17-yl)carbamate

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Chemical Property of benzyl ((6S,9S,11aS,17S,20aS)-6,9,10-trimethyl-5,8,11,16,20-pentaoxohexadecahydro-1H,5H,16Hdipyrrolo[2,1-c:2',1'-l][1]oxa[4,7,10,13]tetraazacyclohexadecin-17-yl)carbamate

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Technology Process of benzyl ((6S,9S,11aS,17S,20aS)-6,9,10-trimethyl-5,8,11,16,20-pentaoxohexadecahydro-1H,5H,16Hdipyrrolo[2,1-c:2',1'-l][1]oxa[4,7,10,13]tetraazacyclohexadecin-17-yl)carbamate

There total 13 articles about benzyl ((6S,9S,11aS,17S,20aS)-6,9,10-trimethyl-5,8,11,16,20-pentaoxohexadecahydro-1H,5H,16Hdipyrrolo[2,1-c:2',1'-l][1]oxa[4,7,10,13]tetraazacyclohexadecin-17-yl)carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

: C₃₃H₄₇N₅O₁₁

: 192068-64-7
benzyl ((6S,9S,11aS,17S,20aS)-6,9,10-trimethyl-5,8,11,16,20-pentaoxohexadecahydro-1H,5H,16Hdipyrrolo[2,1-c:2',1'-l][1]oxa[4,7,10,13]tetraazacyclohexadecin-17-yl)carbamate

Guidance literature:: C₃₃H₄₇N₅O₁₁; With 2,3,4,5,6-pentafluorophenol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; at -20 - 20 ℃; for 12h; Inert atmosphere;

With hydrogenchloride; In 1,4-dioxane; at 20 ℃; for 6h; Inert atmosphere;

With water; sodium hydrogencarbonate; In dichloromethane; at 20 ℃; for 24h; diastereoselective reaction; Inert atmosphere;
DOI:10.1021/np500158q

Reference yield:

: 192068-63-6
(S)-1-((S)-2-{(S)-2-[Methyl-((S)-pyrrolidine-2-carbonyl)-amino]-propionylamino}-propionyl)-pyrrolidine-2-carboxylic acid (S)-2-benzyloxycarbonylamino-2-pentafluorophenyloxycarbonyl-ethyl ester

: 192068-64-7
benzyl ((6S,9S,11aS,17S,20aS)-6,9,10-trimethyl-5,8,11,16,20-pentaoxohexadecahydro-1H,5H,16Hdipyrrolo[2,1-c:2',1'-l][1]oxa[4,7,10,13]tetraazacyclohexadecin-17-yl)carbamate

Guidance literature:: With sodium hydrogencarbonate; In chloroform; for 6h; Yield given; Ambient temperature;
DOI:10.1002/anie.199711101

Reference yield:

: 192068-62-5
C₃₉H₄₆F₅N₅O₁₁

: 192068-64-7
benzyl ((6S,9S,11aS,17S,20aS)-6,9,10-trimethyl-5,8,11,16,20-pentaoxohexadecahydro-1H,5H,16Hdipyrrolo[2,1-c:2',1'-l][1]oxa[4,7,10,13]tetraazacyclohexadecin-17-yl)carbamate

Guidance literature:: Multi-step reaction with 2 steps

1: HCl / dioxane / 2 h / Ambient temperature

2: aq. NaHCO₃ / CHCl₃ / 6 h / Ambient temperature

With hydrogenchloride; sodium hydrogencarbonate; In 1,4-dioxane; chloroform;
DOI:10.1002/anie.199711101