(R)-[N-3-(3-fluoro-4-morpholin-4-ylphenyl)-2-oxo-5-oxazolidinyl]methyl N,O-bis(tert-butoxycarbonyl)hydroxylamine

Base Information

Chemical Name:(R)-[N-3-(3-fluoro-4-morpholin-4-ylphenyl)-2-oxo-5-oxazolidinyl]methyl N,O-bis(tert-butoxycarbonyl)hydroxylamine
CAS No.:503026-31-1
Molecular Formula:C₂₄H₃₄FN₃O₈
Molecular Weight:511.548
Hs Code.:

Synonyms:(R)-[N-3-(3-fluoro-4-morpholin-4-ylphenyl)-2-oxo-5-oxazolidinyl]methyl N,O-bis(tert-butoxycarbonyl)hydroxylamine

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Chemical Property of (R)-[N-3-(3-fluoro-4-morpholin-4-ylphenyl)-2-oxo-5-oxazolidinyl]methyl N,O-bis(tert-butoxycarbonyl)hydroxylamine

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Technology Process of (R)-[N-3-(3-fluoro-4-morpholin-4-ylphenyl)-2-oxo-5-oxazolidinyl]methyl N,O-bis(tert-butoxycarbonyl)hydroxylamine

There total 6 articles about (R)-[N-3-(3-fluoro-4-morpholin-4-ylphenyl)-2-oxo-5-oxazolidinyl]methyl N,O-bis(tert-butoxycarbonyl)hydroxylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 85006-25-3
N,N-di(tert-butoxycarbonyl)hydroxylamine

: 174649-09-3,2180621-71-8
(R)-methyl methanesulfonate

: 503026-31-1
(R)-[N-3-(3-fluoro-4-morpholin-4-ylphenyl)-2-oxo-5-oxazolidinyl]methyl N,O-bis(tert-butoxycarbonyl)hydroxylamine

Guidance literature:: N,N-di(tert-butoxycarbonyl)hydroxylamine; With sodium hydride; In N,N-dimethyl-formamide; mineral oil; at 0 ℃; for 0.5h; Inert atmosphere;

(R)-methyl methanesulfonate; In N,N-dimethyl-formamide; mineral oil; at 20 ℃; for 60h; Inert atmosphere;
DOI:10.1080/14756366.2020.1786082

Reference yield:

: 369-34-6
3,4-difluoronitrobenzene

: 503026-31-1
(R)-[N-3-(3-fluoro-4-morpholin-4-ylphenyl)-2-oxo-5-oxazolidinyl]methyl N,O-bis(tert-butoxycarbonyl)hydroxylamine

Guidance literature:: Multi-step reaction with 6 steps

1.1: N-ethyl-N,N-diisopropylamine / ethyl acetate / 20 °C

2.1: ammonium formate; palladium 10% on activated carbon / methanol; tetrahydrofuran

3.1: acetone; water / 20 °C

4.1: n-butyllithium / tetrahydrofuran / -78 °C

5.1: triethylamine / dichloromethane / 0 - 20 °C

6.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.5 h / 0 °C / Inert atmosphere

6.2: 64 h / 0 - 20 °C

With n-butyllithium; palladium 10% on activated carbon; ammonium formate; sodium hydride; triethylamine; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; methanol; dichloromethane; water; ethyl acetate; N,N-dimethyl-formamide; acetone; mineral oil;
DOI:10.1016/j.ejmech.2015.10.025

Reference yield:

: 2689-39-6
3-fluoro-4-(4-morpholinyl)nitrobenzene

: 503026-31-1
(R)-[N-3-(3-fluoro-4-morpholin-4-ylphenyl)-2-oxo-5-oxazolidinyl]methyl N,O-bis(tert-butoxycarbonyl)hydroxylamine

Guidance literature:: Multi-step reaction with 5 steps

1.1: ammonium formate; palladium 10% on activated carbon / methanol; tetrahydrofuran

2.1: acetone; water / 20 °C

3.1: n-butyllithium / tetrahydrofuran / -78 °C

4.1: triethylamine / dichloromethane / 0 - 20 °C

5.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.5 h / 0 °C / Inert atmosphere

5.2: 64 h / 0 - 20 °C

With n-butyllithium; palladium 10% on activated carbon; ammonium formate; sodium hydride; triethylamine; In tetrahydrofuran; methanol; dichloromethane; water; N,N-dimethyl-formamide; acetone; mineral oil;
DOI:10.1016/j.ejmech.2015.10.025