9-chloro-2-(5-(3-(dimethylamino)propyl)-2-isopropylphenylamino)-5H-benzo[b]pyrimido[4,5-d]azepin-6(7H)-one

Base Information

Chemical Name:9-chloro-2-(5-(3-(dimethylamino)propyl)-2-isopropylphenylamino)-5H-benzo[b]pyrimido[4,5-d]azepin-6(7H)-one
CAS No.:1350816-48-6
Molecular Formula:C₂₆H₃₀ClN₅O
Molecular Weight:464.01
Hs Code.:

Synonyms:9-chloro-2-(5-(3-(dimethylamino)propyl)-2-isopropylphenylamino)-5H-benzo[b]pyrimido[4,5-d]azepin-6(7H)-one

Suppliers and Price of 9-chloro-2-(5-(3-(dimethylamino)propyl)-2-isopropylphenylamino)-5H-benzo[b]pyrimido[4,5-d]azepin-6(7H)-one

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 9-chloro-2-(5-(3-(dimethylamino)propyl)-2-isopropylphenylamino)-5H-benzo[b]pyrimido[4,5-d]azepin-6(7H)-one

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 9-chloro-2-(5-(3-(dimethylamino)propyl)-2-isopropylphenylamino)-5H-benzo[b]pyrimido[4,5-d]azepin-6(7H)-one

There total 12 articles about 9-chloro-2-(5-(3-(dimethylamino)propyl)-2-isopropylphenylamino)-5H-benzo[b]pyrimido[4,5-d]azepin-6(7H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 61.0%

: C₁₅H₂₆N₄*ClH

: 87379-40-6
8-chloro-4<(dimethylamino)methylidene>-3,4-dihydro-1H-1-benzazepine-2,5-dione

: 1350816-48-6
9-chloro-2-(5-(3-(dimethylamino)propyl)-2-isopropylphenylamino)-5H-benzo[b]pyrimido[4,5-d]azepin-6(7H)-one

Guidance literature:: With potassium carbonate; In ethanol; at 125 ℃; Inert atmosphere;
DOI:10.1021/jm2011172

Reference yield:

: 5900-58-3
2-amino-4-chloro-benzoic acid methyl ester

: 1350816-48-6
9-chloro-2-(5-(3-(dimethylamino)propyl)-2-isopropylphenylamino)-5H-benzo[b]pyrimido[4,5-d]azepin-6(7H)-one

Guidance literature:: Multi-step reaction with 5 steps

1.1: dmap; N-ethyl-N,N-diisopropylamine / dichloromethane / 20 °C

2.1: potassium tert-butylate / tetrahydrofuran / 10 °C

2.2: 20 °C / pH 4

3.1: water / dimethyl sulfoxide / 150 °C / Cooling

3.2: 0 °C

4.1: tetrahydrofuran / 2 h / 60 °C / Inert atmosphere

5.1: potassium carbonate / ethanol / 125 °C / Inert atmosphere

With dmap; potassium tert-butylate; water; potassium carbonate; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; ethanol; dichloromethane; dimethyl sulfoxide; 2.1: Dieckmann reaction;
DOI:10.1021/jm2011172

Reference yield:

: 1350816-43-1
(2E)-3-(4-bromo-3-nitrophenyl)-N,N-dimethylacrylamide

: 1350816-48-6
9-chloro-2-(5-(3-(dimethylamino)propyl)-2-isopropylphenylamino)-5H-benzo[b]pyrimido[4,5-d]azepin-6(7H)-one

Guidance literature:: Multi-step reaction with 6 steps

1.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate / 1,2-dimethoxyethane; water / 15 h / 80 °C

2.1: palladium 10% on activated carbon; hydrogen / ethyl acetate

3.1: borane-THF / tetrahydrofuran / 2.5 h / Inert atmosphere; Reflux

3.2: 75 °C

4.1: mercury (II) chloride; triethylamine / dichloromethane / 20 °C / Inert atmosphere

5.1: hydrogenchloride / 1,4-dioxane / 20 °C

6.1: potassium carbonate / ethanol / 125 °C / Inert atmosphere

With hydrogenchloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; borane-THF; palladium 10% on activated carbon; hydrogen; sodium carbonate; potassium carbonate; mercury (II) chloride; triethylamine; In tetrahydrofuran; 1,4-dioxane; 1,2-dimethoxyethane; ethanol; dichloromethane; water; ethyl acetate;
DOI:10.1021/jm2011172