(2S,3R)-3-Amino-2-hydroxy-4-phenylbutyric acid hydrochloride

Base Information

• Chemical Name: (2S,3R)-3-Amino-2-hydroxy-4-phenylbutyric acid hydrochloride
• CAS No.: 140409-01-4
• Molecular Formula: C₁₀H₁₉NO₃*ClH
• Molecular Weight: 237.727
• Mol file: 140409-01-4.mol

Synonyms:(2S,3R)-3-Amino-2-hydroxy-4-phenylbutyric acid hydrochloride

Chemical Property of (2S,3R)-3-Amino-2-hydroxy-4-phenylbutyric acid hydrochloride

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (2S,3R)-3-Amino-2-hydroxy-4-phenylbutyric acid hydrochloride

There total 15 articles about (2S,3R)-3-Amino-2-hydroxy-4-phenylbutyric acid hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

2-acetoxy-4-cyclohexyl-3-(isopropoxycarbonylamino) butyronitrile (128540-55-6,129024-24-4) → (3S)-3-amino-4-cyclohexyl-2-hydroxybutyric acid hydrochloride (113785-82-3,121506-22-7,126832-05-1,140409-01-4)

Guidance literature:

With hydrogenchloride; In ethyl acetate; at 80 - 100 ℃; for 14h;

DOI:10.1246/bcsj.65.360

Reference yield: 98.0%

(2S,3R,5R,6S)-3-cyclohexylmethyl-5,6-diphenylmorpholine-2-carboxylic acid (339161-01-2) → (2S,3R)-3-Amino-2-hydroxy-4-phenylbutyric acid hydrochloride (140409-01-4)

Guidance literature:

With hydrogen; palladium dichloride; In tetrahydrofuran; water; at 75 ℃; for 3h; under 6205.94 Torr;

DOI:10.1021/ja0042332

Reference yield: 50.0%

Acetic acid (R)-1-cyano-3-cyclohexyl-2-isopropoxycarbonylamino-propyl ester (128540-55-6,129024-24-4) → (2S,3R)-3-Amino-2-hydroxy-4-phenylbutyric acid hydrochloride (140409-01-4)

Guidance literature:

With hydrogenchloride; at 80 - 100 ℃;

upstream raw materials:

Acetic acid (R)-1-cyano-3-cyclohexyl-2-isopropoxycarbonylamino-propyl ester

(3R,4S)-3-Triisopropylsilyloxy-4-(cyclohexylmethyl)-2-azetidinone

(2S,3R,5R,6S)-3-cyclohexylmethyl-5,6-diphenylmorpholine-2-carboxylic acid

(3R,5R,6S)-2-cyano-3-cyclohexylmethyl-5,6-diphenylmorpholine-4-carboxylic acid benzyl ester

Downstream raw materials:

isopropyl (2R,3R)-3-<-L-histidyl>amino>-4-cyclohexyl-2-hydroxybutyrate

isopropyl (2R,3R)-3-amino-4-cyclohexyl-2-hydroxybutyrate hydrochloride

isopropyl (2S,3S)-3-<-L-histidyl>amino>-4-cyclohexyl-2-hydroxybutyrate

(4S,5S)-4-(cyclohexylmethyl)-5-(isopropoxycarbonyl)-2-oxazolidinone