(R)-1-(4-(2-fluoroethoxy)phenyl)-4-(4-(7-hydroxychroman-2-yl)-3-azabutyl)piperazine

Base Information

Chemical Name:(R)-1-(4-(2-fluoroethoxy)phenyl)-4-(4-(7-hydroxychroman-2-yl)-3-azabutyl)piperazine
CAS No.:1526935-23-8
Molecular Formula:C₂₄H₃₂FN₃O₃
Molecular Weight:429.535
Hs Code.:

Synonyms:(R)-1-(4-(2-fluoroethoxy)phenyl)-4-(4-(7-hydroxychroman-2-yl)-3-azabutyl)piperazine

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Chemical Property of (R)-1-(4-(2-fluoroethoxy)phenyl)-4-(4-(7-hydroxychroman-2-yl)-3-azabutyl)piperazine

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Technology Process of (R)-1-(4-(2-fluoroethoxy)phenyl)-4-(4-(7-hydroxychroman-2-yl)-3-azabutyl)piperazine

There total 9 articles about (R)-1-(4-(2-fluoroethoxy)phenyl)-4-(4-(7-hydroxychroman-2-yl)-3-azabutyl)piperazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

: 1526935-32-9
(R)-1-(4-(2-fluoroethoxy)phenyl)-4-(4-(7-(methoxymethoxy)chroman-2-yl)-3-azabutyl)piperazine

: 1526935-23-8
(R)-1-(4-(2-fluoroethoxy)phenyl)-4-(4-(7-hydroxychroman-2-yl)-3-azabutyl)piperazine

Guidance literature:: With hydrogenchloride; In 1,4-dioxane; isopropyl alcohol; at 20 ℃; for 3h; Inert atmosphere;
DOI:10.1021/jm401384w

Reference yield:

: 124439-98-1
(R)-7-hydroxychroman-2-carboxylic acid ethyl ester

: 1526935-23-8
(R)-1-(4-(2-fluoroethoxy)phenyl)-4-(4-(7-hydroxychroman-2-yl)-3-azabutyl)piperazine

Guidance literature:: Multi-step reaction with 5 steps

1: N-ethyl-N,N-diisopropylamine / dichloromethane

2: lithium borohydride / tetrahydrofuran / 2 h / 20 °C / Cooling with ice

3: pyridine / 0 - 4 °C

4: N-ethyl-N,N-diisopropylamine / dimethyl sulfoxide / 100 °C / Inert atmosphere

5: hydrogenchloride / 1,4-dioxane; isopropyl alcohol / 3 h / 20 °C / Inert atmosphere

With pyridine; hydrogenchloride; lithium borohydride; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; 1,4-dioxane; dichloromethane; dimethyl sulfoxide; isopropyl alcohol;
DOI:10.1021/jm401384w

Reference yield:

: 1526935-44-3
1-(2-N-(tert-butylcarbamate)ethyl)-4-(4-(4-fluoroethoxy)phenyl)piperazine

: 1526935-23-8
(R)-1-(4-(2-fluoroethoxy)phenyl)-4-(4-(7-hydroxychroman-2-yl)-3-azabutyl)piperazine

Guidance literature:: Multi-step reaction with 3 steps

1: hydrogenchloride / water / 0.33 h / 20 °C

2: N-ethyl-N,N-diisopropylamine / dimethyl sulfoxide / 100 °C / Inert atmosphere

3: hydrogenchloride / 1,4-dioxane; isopropyl alcohol / 3 h / 20 °C / Inert atmosphere

With hydrogenchloride; N-ethyl-N,N-diisopropylamine; In 1,4-dioxane; water; dimethyl sulfoxide; isopropyl alcohol;
DOI:10.1021/jm401384w